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All Journal The Journal of Pure and Applied Chemistry Research ANNALES BOGORIENSES
Akhmad Darmawan
Research Center for Chemistry, Indonesian Institute of Sciences
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Journal : ANNALES BOGORIENSES

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Identification of a New Compound as α-Glucosidase Inhibitor from Aspergillus aculeatus Rizna Triana Dewi; Asep Suparman; Hanny Mulyani; Akhmad Darmawan; Puspa Dewi Narrij Lotulung
ANNALES BOGORIENSES Vol 20, No 1 (2016): Annales Bogorienses
Publisher : Research Center for Biotechnology - Indonesian Institute of Sciences (LIPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.264 KB) | DOI: 10.14203/ann.bogor.2016.v20.n1.19-23

Abstract

Terestrial fungi are of great importance as potential sources of pharmaceutical agent. Aspergillus aculeatus, a fungus isolated from soil sample collected in Indonesia, was cultured in liquid media to investigate a novel compound as inhibitor α-glucosidase. The mycelium extract of A. aculeatus shows potential activity against Saccharomyces cereviseae α-glucosidase and mild activity against mammalian α-glucosidase with IC50 values of 9.57 µg/mL and 470.76 mg/mL, respectively. Enzyme assay-guided fractionation of this extract afforded rubrofusarin (1). Rubrofusarin, a linear naphtho-γ-pyrone, is a natural pigment from Aspergillus sp. Interestingly, compound 1 shows potential inhibitory activity against mammalian α-glucosidase (IC50 of 92.7 µg/mL), but no to S. cereviseae α-glucosidase. The results suggest that A. aculeatus is a promising natural source as a lead compound in the discovery of antidiabetic drug.
Co-Authors Asep Suparman Gian Primahana Hanny Mulyani Puspa Dewi Narrij Lotulung Rizna Triana Dewi