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All Journal Majalah Kedokteran Bandung Nexus Kedokteran Komunitas
yoseph Indrayanto
Laboratorium Biologi Fakultas Kedokteran, Universitas Sebelas Maret Surakarta
Medicine & Pharmacology

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Hubungan Antara Stres Psikis Menjelang UAN dan SNMPTN dengan Kejadian Fluor Albus pada Siswi SMA Peserta Bimbingan Belajar Fransisca, Jeanne; Indrayanto, Yoseph; Riyadi, Slamet
Nexus Kedokteran Komunitas Vol 2, No 3 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: The incidence number of psychological stress before UAN and SNMPTN in XII grade of high school students is quite high. This is so adverse because psychological stress itself could affect students’ health. For example, psychological stress could be a cause of whitish or fluor albus in female students. If this is ignored, it would be dangerous. For those reasons, this research was done to reveal the relation between psychological stress before UAN and SNMPTN to fluor albus incidence in female high school study course participants. Methods: The method of this research was analytical observation with cross sectional approach. The subject was female high school students grade XII and participants of study course in Surakarta. Author used purposive sampling as sampling technique and to gather the data author usedLie-Minnesota Multiphasic Personality Inventory (L-MMPI) questionnaires, anxiety facing UAN and SNMPTN questionnaires, DASS42 questionnaires, and fluor albus incidence questionnaires. Data were collected from 60 samples and was analyzed by Chi Square (X2) test and Coefficient Continquency (CC. Results: From this research, author obtained X2 score value(5,406) is bigger than X2 tablevalue (3,841) with signification rate (α) = 0,05 and independence degree (df) = 1. As for the p value obtained (0,02) is smaller than the significance level which is already defined previously (0,05). Those were shown that H0 was rejected. Data analysis was continue to Coefisien Continquency (CC) test which then obtained the value of CC = 0,287. It means that the relation is weak. Conclusion: There was a weak relation statistically between psychological stress before national examination (UAN) and national university entrance examination (SNMPTN) to fluor albus incidence in female high school study course participants. Keywords: Psychological Stress, UAN, SNMPTN, Fluor Albus 
Hubungan antara Kecemasan dengan Masa Menopause pada Wanita Harnani, Kharisma Setya; Indrayanto, Yoseph; Dharmawan, Ruben
Nexus Kedokteran Komunitas Vol 2, No 3 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background : Menopause is the transition of the reproductive period to the nonreproductive period which happens in women due to the decreased levels of the esterogen and progesterone hormones. There are several symptoms during the menopause period such as physical symptoms, somatic disorders, sexual disorders, and physical disorders. This research aims to describe the relation between anxiety and menopause in women. Methodology : This research is observational analytic research with cross sectional approach. This research was conducted in Posyandu Lansia Dahlia RW XIX Nusukan, Posyandu Lansia RW XIV Nusukan, and Posyandu Lansia Pucangsawit. The samples of this research are the women who had no menstrual period for 1-2 years, women ≥ 40 years old which are not in menopause period yet (control), women with unpathological menopause, L-MMPI scores with “NO” answers < 10, and the women who are able to be the respondents to fill in and accept the informed consent. This research employs the purposive random sampling technique in which samples are selected based on the characteristics of the research inclusion and exclusion. The dependent variable in this research is menopause and the independent variable is anxiety. The subject of the research filled (1) the curriculum vitae and informed consent, (2) L-MMPI questionnaire to checked the respondent’s truthfulness in filling the questionnaire, (3) TMAS questionnaire to found out the anxiety scores. The data which were obtained  are 60 respondents, then the data were analyzed using Chi Square (x2) then Coeficient Contingency (C). Result : Based on the data analysis, p = 0.01 was obtained from α = 0.05 which means p < 0.05 and the relation is 0.317. Conclusion : Statistically, there is significant relation with weak correlation between anxiety and menopause period in women.   Keywords : Menopause, Anxiety 
Hubungan antara Penerimaan Diri dengan Kecemasan pada Wanita Menopause Dewanti, Dyah Mustikaningtyas; Indrayanto, Yoseph; Dharmawan, Ruben
Nexus Kedokteran Komunitas Vol 2, No 3 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Anxiety of menopausal women may appear because they have to adjust to the aging process. Anxiety will become pressure and burden if she always thinks negatively. Self-acceptance is the ability of individuals to accept themselves which is characterized by self-confidence and self-appreciation. Self-acceptance can reduce the possibility of a person to think of anything that can stimulate anxiety. This study aims to determine the relation between self-acceptance and anxiety of menopausal women. Method: This research was observational analytic study with cross-sectional approach by using purposive random sampling technique. This research was conducted from March to April 2013 at Posyandu Dahlia RW XIX Nusukan, Posyandu RW XIV Nusukan and Posyandu Pucang Sawit. The number of sample was 35 menopausal women who were appropriate to the inclusion criteria. The sampling of this research are the women who had menopause for 1-2 years, women with unpathological menopause, L-MMPI scores with “NO” answers <10, and the women who are able to be the respondents to fill in and accept the informed consent. The subject of the research filled (1) informed consent (2) curriculum vitae form (3) L-MMPI questionnaire to evaluate the respondent’s truthfulness in answering questionnaire (4) Berger’s Self-Acceptance Scale questionnaire to find out the self-acceptance score (5) Taylor Manifest Anxiety Scale questionnaire to find out the anxiety score. Data were analyzed using Pearson Product Moment correlation test through SPSS 17.00 for Windows. Result: Based on the data analysis, p = 0.0001 (p < 0.05) and Pearson correlation value (r) = -0.627. Conclusion: There is a strong negative correlation between self-acceptance and anxiety of menopausal women. Keywords: self-acceptance, anxiety, menopausal women  
Hubungan antara Menopause Dengan Hipertensi di Puskesmas Penumping Surakarta Raharjo, Dendy; Indrayanto, Yoseph; Riyadi, Slamet
Nexus Kedokteran Komunitas Vol 2, No 3 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background:Hypertension is here defined as systolic arterial blood pressure at least 140 mmHg or diastolic arterial blood pressure at least 90 mmHg or taking anti-hypertensive drugs. Onset varietyof hypertension is influenced by various factors, one of which is menopause. In this study,sample data of menopausewas obtained by using questionnaire sheet. The purpose of this study is to determine the relationship between menopause and hypertension. Methods:This study is an observational analysis with cross sectional study approach. The sampling technique employed was purposive sampling. Sample size comprises 47 female patients. The research was conducted in July 2013 at Penumping Community Health Center, Surakarta. Data was obtained by questionnaire and direct measurement of the weight and height. The statistical analysis used was Chi-Square. Results:Chi-Square analysis results obtained p = 0.046 (p <0.05). This analysis showed significant association between menopause and hypertension in Penumping Community Health Center Surakarta. Conclusions:Based on this study it can be concluded that there is a positive relationship between  menopause and hypertension. Keywords:menopause , hypertension 
Efek Probiotik terhadap Mortalitas, Derajat Inflamasi Intestinal, dan Kadar IgA pada Mencit Model Sepsis Indrayanto, Yoseph; Prasetyo, Diding Heri
Majalah Kedokteran Bandung Vol 45, No 1 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Sepsis mengubah mikrobiologi saluran pencernaan, menyebabkan hilangnya flora komensal dan pertumbuhan bakteri patogen yang berlebih. Pemberian probiotik penderita sepsis dapat mengembalikan keseimbangan mikrobiota dan memiliki efek positif pada fungsi imunitas tubuh serta struktur dan fungsi gastrointestinal. Penelitian ini bertujuan untuk menentukan efek pemberian probiotik terhadap mortalitas, inflamasi intestinal, dan kadar imunoglobulin A (IgA) serum pada mencit model sepsis. Penelitian ini merupakan penelitian eksperimental laboratoris, dengan sampel 36 ekor mencit Balb/C jantan dibagi menjadi kelompok: kontrol, sepsis, dan sepsis+probiotik. Penelitian dilakukan di laboratorium Histologi dan Biomedik Fakultas Kedokteran Universitas Sebelas Maret Surakarta,periode Januari–April 2012. Mencit Balb/C jantan diinjeksi cecal inoculum (200 mg/kgBB) secara intraperitoneal (i.p), untuk kelompok sepsis maupun sepsis dengan probiotik. Kelompok mencit kontrol tidak diinokulasi selama penelitian. Inflamasi intestinal ditentukan dengan pengecatan hematoksilin eosin (HE) pada hari ke-8. Mortalitas dinilai sampai hari ke-8. Kadar IgA serum ditentukan menggunakan enzyme-linked immunosorbent assay. Twotailed Fisher Exact Test untuk uji mortalitas, Kruskal-Wallis untuk uji inflamasi intestinal, sedangkan analysis of variance untuk uji kadar IgA serum. Persentase kematian kelompok probiotik tidak berbeda bermakna (10% vs 40%, p=0,065) dibandingkan dengan kelompok sepsis. Probiotik bermakna menurunkan derajat inflamasi intestinal dibandingkan dengan kelompok sepsis (p<0,001). Kadar IgA serum kelompok mencit kontrol 35,82±4,55 ng/mL. Probiotik secara bermakna meningkatkan kadar IgA serum (65,07±34,97 ng/mL vs 6,20±5,80 ng/mL, p<0,001) dibandingkan dengan kelompok mencit sepsis. Simpulan, pemberian probiotik menurunkan derajat inflamasiintestinal dan mortalitas, serta meningkatkan kadar IgA serum pada mencit model sepsis. [MKB. 2013;45(1):10–5]Kata kunci: IgA, inflamasi, probiotik, sepsis Probiotic Effects of Mortality, Degree of Intestinal Inflammation, and IgA Levels in Sepsis Mice ModelSepsis results in changes to the microbiology of the gastrointestinal tract, leading to a loss of commensal flora and an overgrowth of potentially pathogenic bacteria. Administering probiotics to sepsis patients may restore balance to the microbiota and have positive effects on immune function and gastrointestinal structure and function. This study was aimed to evaluate the effect of probiotic on mortality, intestinal inflammation and immunoglobulin A (IgA) serum level in mice model of sepsis. This study was an experimental research laboratory, with 36 male Balb/C mice were divided into: control, sepsis, and sepsis+probiotic groups. The study was conducted at Histology and Biomedical Laboratory, School of Medicine, Sebelas Maret University, Surakarta, in January to April 2012. Sepsis was induced in the male Balb/C mice using an intraperitoneally (i.p) injection of cecal inoculum (200 mg/ kgBW), for sepsis mice model and sepsis with probiotic. Control mice were not inoculation during the study. Detection of intestinal inflammation with hematoxylin and eosin (HE) staining on 8th day. Mortality perceived until 8th day. IgA serum level measurement with enzyme-linked immunosorbent assay. Two-tailed Fisher exact test for the analysis of mortality, Kruskal-Wallis test for the intestinal inflammation, one way analysis of variance for IgA serum level. Probiotic showed no significantly mortality (10% vs 40%, p=0.065) compared to sepsis group. Probiotic showed significantly decreased intestinal inflammation compared to sepsis group (p<0.001). Control mice showed levels of IgA 35.82±4.55 ng/mL. Probiotic showed significantly increased IgA levels (65.07±34.97 ng/mL vs 6.20±5.80 ng/mL, p<0.001) compared to sepsis group. In conclusions, probiotic decrease intestinal inflammation and mortality, on the other hand increase IgA level in mice model of sepsis. [MKB. 2013;45(1):10–5]Key words: IgA, inflammation, probiotic, sepsis DOI: http://dx.doi.org/10.15395/mkb.v45n1.95
PENURUNAN KADAR PRO-ADRENOMEDULLIN MENCIT BALB/C MODEL SEPSIS DENGAN KORTIKOSTEROID DOSIS RENDAH Prasetyo, Diding Heri; Nurwati, Ida; Indrayanto, Yoseph; Hermawan, A. Guntur
Majalah Kedokteran Bandung Vol 46, No 2 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Penggunaan kortikosteroid dosis rendah pada penatalaksanaan sepsis tahap awal masih diperdebatkan. Pemberian kortikosteroid dosis rendah pada sepsis dapat mengurangi respons inflamasi sitemik, menghambat produksi sitokin proinflamasi dan mediator inflamasi, serta menurunkan adhesi leukosit ke endotel. Pro-adrenomedullin (pro-ADM) merupakan biomarker keparahan sepsis. Penelitian ini bertujuan untuk menganalisis efek penggunaan kortikosteroid dosis rendah pada kadar pro-ADM serum pada mencit Balb/C model sepsis tahap awal. Penelitian ini merupakan penelitian eksperimental laboratoris, dengan sampel 30 ekor mencit Balb/C jantan yang dibagi menjadi kelompok kontrol, sepsis, dan sepsis+kortikosteroid dosis rendah. Penelitian dilakukan di Laboratorium Histologi dan Biomedik, Fakultas Kedokteran, Universitas Sebelas Maret Surakarta, selama periode April?September 2012. Untuk membuat model sepsis, hewan coba diinokulasi lipopolisakarisa/LPS (E. coli) dosis 0,1 mg/mencit secara intraperitoneal (i.p). Kelompok tikus kontrol tidak diinokulasi selama penelitian. Kortikosteroid dosis rendah yang digunakan adalah metil prednisolon dosis 0,05 mg/mencit/12 jam secara i.p. Mencit kontrol tidak diinokulasi selama penelitian. Kadar pro-ADM serum ditentukan menggunakan enzyme-linked immunosorbent assay (ELISA). Uji kadar pro-ADM serum menggunakan analysis of variance (ANOVA) dan untuk menentukan perbedaan kemaknaan digunakan p<0,05. Kortikosteroid dosis rendah secara bermakna menurunkan kadar pro-ADM dibandingkan dengan kelompok sepsis (33,0±2,9 pg/mL vs 48,5±6,1 pg/mL; p<0,001). Simpulan, penggunaan kortikosteroid dosis rendah menurunkan kadar pro-ADM pada hewan coba model sepsis tahap awal. [MKB. 2014;46(2):68?72]Kata kunci: Kortikosteroid dosis rendah, pro-adrenomedullin, sepsisPro-adrenomedullin Level Reduction in Balb/C Sepsis Model Mice through the Use of Low-Dose CorticosteroidThe use of low-dose corticosteroids in the management of early stage of sepsis is still debated. Low-dose corticosteroids in sepsis can reduce the systemic inflammatory response, inhibit the production of pro-inflammatory cytokine, inflammatory mediators, and decrease adhesion of leukocytes to the endothelium. Pro-adrenomedullin (pro-ADM) is a biomarker of sepsis severity. This study aimed to analyze the effects of the use of low-dose corticosteroids on the levels of pro-ADM in the serum in Balb/C mice model of sepsis at the early stage. This study was an experimental research laboratory, with 30 male Balb/C mice which were divided into control, sepsis, and sepsis+low-dose corticosteroids groups. The study was conducted at the Histology and Biomedical Laboratory, Faculty of Medicine, Sebelas Maret University, Surakarta, during the period of April to September 2012. Sepsis was induced in the male Balb/C mice by inoculation through an intraperitoneally (i.p) injection of lipopolysaccharide/LPS (E. coli) with 0.1 mg/mice/i.p. dose for sepsis mice model. Control mice were not inoculated during the study. Low-dose corticosteroids used was methyl prednisolone at a dose of 0.05 mg/mice/12 hours/i.p. Pro-ADM serum level was measured with enzyme-linked immunosorbent assay (ELISA). One way analysis of variance (ANOVA) for pro-ADM serum level and p<0.05 were used to determine the significant differences. Low-dose corticosteroids significantly decreased pro-ADM level (33.0±2.9 pg/mL vs 48.5±6.1 pg/mL, p<0.001) compared to the sepsis group. In conclusion, the use of low-dose corticosteroids reduce levels of pro-ADM in the early stages of sepsis. [MKB. 2014;46(2):68?72]Key words: Low-dose corticosteroids, pro-adrenomedullin, sepsis DOI: 10.15395/mkb.v46n2.276
Co-Authors A. Guntur Hermawan Dendy Raharjo Diding Heri Prasetyo Dyah Mustikaningtyas Dewanti Ida Nurwati Jeanne Fransisca Kharisma Setya Harnani RUBEN DHARMAWAN Slamet Riyadi