Article Per Year (5 Year)
p-Index From 2018 - 2023
0.659
P-Index
This Author published in this journals
All Journal Medicina journal of internal medicine E-Jurnal Medika Udayana Indonesian Journal of Rheumatology Jurnal Penyakit Dalam Udayana Cermin Dunia Kedokteran
Gede Kambayana
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
KORELASI KADAR MATRIX METALLOPROTEINASES 3 (MMP-3) DENGAN DERAJAT BERATNYA OSTEOARTRITIS LUTUT Eka Imbawan, IGN; Raka Putra, Tjokorda; Kambayana, Gede
journal of internal medicine Vol. 12, No. 3 September 2011
Publisher : journal of internal medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (136.187 KB)

Abstract

Osteoarthritis (OA) is one type of arthritis which commonly found especially in elderly and become the common cause ofdisability in elderly people. Recently known that immunologic respons and homeostasis of cartilage metabolism have animportant role, and MMP-3 as one of degradative enzyme which has a pivotal role in OA patogenesis. Aim of this studyis to determine correlation between level of MMP-3 and radiographic grading of knee OA, in Sanglah Hospital, DenpasarBali. An analytical cross sectional study was carried out in Policlinic Sanglah Hospital, enrolled 76 samples with kneeOA. Of all sample, 32 (42.1%) were males and 44 (57.9%) famales. The mean of MMP-3 serum level is 25.2 ± 20.7ng/ml. Radiographic grading of knee OA based on Kelgren and Lawrence criteria 4 (5.3%) grade 1,29 (38.3%) grade 2,28 (36.8%) grade 3 and 15 (19.7%) grade 4. The mean level of MMP-3 on grade 1 group is (24.7 ng/ml), grade 2 (17.8ng/ml), grade 3 (28.3 ng/ml) and grade 4 is 32.8 ng/ml. Using Spearman!s analyses, there were signiÞ cant correlationbetween MMP-3 and radiographic grading of knee OA (r = 0.25 and p = 0.03).There were signiÞ cant positive correlation between MMP-3 and radiographic grading of knee OA.
INSUFFISIENSI KATUP MITRAL PADA SEORANG PENDERITA LUPUS ERITEMATOSUS SISTEMIK Sanjaya, Surya; Kambayana, Gede; Rina, I K; Raka Putra, Tjokorda
journal of internal medicine Vol. 9, No. 3 September 2008
Publisher : journal of internal medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.308 KB)

Abstract

Systemic lupus erythematosus (SLE) is a multisystem inflammatory disease that is often difficult to diagnose and theetiology still unclear. Before the diagnosis can be established, four of eleven clinical and laboratory criteria must be met. Theprogression of SLE is acute fulminant, chronic remision and exacerbation. Prevalens of SLE in the many countries is variouslybetween 2.9 ? 400 per 100.000. SLE usually occur in reproduction period of human (15 ? 40 years old) and female is morecommon than male 5.5 ? 9.0 : 1. Cardiovascular manifestation of SLE is an serious case and increasing of mortality. Pericarditis,miocarditis and fibrinous Libmann-Sacks endocarditis are a common cardiovascular manifestation. Insufficiency of mitral andaorta valve is a rare complication of SLE and usually combination with pulmonal vein congestion and lung edema. We reporteda systemic lupus erythematosus with insufficiency mitral valve in Sanglah hospital because this case is very rare in populationand complicated. Accurate diagnosis of SLE is important because prompt treatment can reduce morbidity and mortality.
Seorang pasien yang menderita sklerosis sistemik konkomitan dengan artritis reumatoid Yuliandari KK, Cok Istri; Kambayana, Gede
Medicina Vol 47 No 3 (2016): September 2016
Publisher : Medicina

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (102.582 KB)

Abstract

Sklerosis sistemik (SS) dan artritis reumatoid (AR) merupakan penyakit jaringan ikat yang bersifat kronik progresif.Sklerosis sistemik ditandai dengan fibrosis abnormal, sedangkan AR ditandai dengan gangguan pada persendian yangsimetris. Sklerosis sistemik merupakan penyakit yang jarang. Kedua penyakit ini dapat terpisah atau terjadi bersamaanyang disebut denganoverlap syndrome. Kami melaporkan sebuah kasus SS dan AR yang secara konkomitan terjadipada seorang pasien. Wanita, usia 30 tahun, suku bali, yang ditemukan dengan penebalan, penegangan, danpengerasan pada kulit seluruh tubuh yang dialami sejak 4 tahun yang lalu. Pada pasien juga ditemukan deformitas(swan neck deformity) simetris pada sendi jari tangan dan kaki. Anti-topoimerase 1 (anti-scl 70) positif, biopsi kulitmenunjukkan suatu skleroderma, foto manus dan pedis menunjukkan gambaran erosi marginal. Pasien memenuhikriteria diagnosis SS dan AR, dandiberiterapi metroteksat 7,5 mg setiap minggu, denganprognosis dubius ad malam.[MEDICINA.2016;50(3):42-46]Systemic sclerosis (SS) andrheumatoidarthritis (RA) are a chronic and progressive of connective tissue diseases.Systemic sclerosis presented by abnormal fibrosis, whileRA is presented bysymmetrical joint lesion. Systemicsclerosis is a rare case. Systemic sclerosis and RA can affect the patient separately or both can occurred in oneindividual, called overlaps syndrome. We reported a case of SS and RA overlaps syndrome. Athirtyyear old Balinesefemale patient found with a thickening, tightness,andhardening of her skin, occurred since 4 years. We also found theswan neck deformities on her fingers and toessymmetrically. Anti-topoimerase (anti-scl 70) positive, skin biopsyshowed scleroderma, manus and pedis x-ray showed the marginal erosion. The patient fulfilled criteria diagnosis forSS and RA. The patient was given metrotexat 7.5 mg each week, and the prognosis was dubius ad malam.[MEDICINA.2016;50(3):42-46]
Correlation between Severity of Knee Osteoarthritis and Serum Levels of Cartilage Oligomeric Matrix Protein Kambayana, Gede; Kurniari, Pande; Andriyasa, Andriyasa; Putra, T R
Indonesian Journal of Rheumatology Vol 5, No 1 (2014)
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (217.032 KB)

Abstract

Background: The sensitivity of radiographic examination in the diagnosis and severity assessment of knee osteoarthritis (OA) is still low. Various attempts have been made to find more reliable indicators of cartilage damage. One potential marker is cartilage oligomeric matrix protein (COMP), a substance that in previous animal studies had been shown to be released in proportion to the extent of joint cartilage damage.Objective: To evaluate the correlation between the severity of knee OA and serum level of COMP in human with normal renal function. Methods: This was a cross-sectional study performed at the outpatient clinic in Department of Internal Medicine, Sanglah Hospital, Denpasar. The diagnosis of knee OA was based on the American College of Rheumatology (ACR) criteria. The degreeof knee OA severity was determined by using the Kellgren-Lawrence criteria, while COMP values were checked by enzyme-linked immunosorbent assay (ELISA) method.Results: Forty five patients who were recruited were examined: 19 (42.2%) were female and 26 (57.8%) were male. The mean age of patients was 64.1±7.1 years. There were 4.4%, 26.7%, 46.7%, and 22.2% patients who had grade 1st, 2nd, 3rd, and 4th degree joint damage based on the Kellgren-Lawrence score, respectively. Mean serum level of COMP was 1081.4 ng/mL. We found a significant correlation ofthe severity of knee OA with serum level of COMP (r = 0.41, p = 0.005).Conclusion: Among the patients in this study, there was a significant correlation between the severity of joint damage in knee OA and serum level of COMP.
Comparison of the prevalence of hyperuricemia in families of patients with and without gouty arthritis among Balinese people Kambayana, Gede; Putra, T R
Indonesian Journal of Rheumatology Vol 3, No 1 (2011)
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (113.802 KB)

Abstract

Background: Gout is a metabolic disorder caused by hyperuricemia, which results from changes in uric acid metabolism. Both internal (e.g., genetics) and external factors (e.g., diet, habits, comorbidities) play role in the occurrence of hyperuricemia and the difference of hyperuricemia prevalence in different populations.Objective: To compare the prevalence of hyperuricemia in families of gout and non-gout patients among Balinese people.Methods: This cross-sectional study was carried out at the rheumatology clinic at Sanglah Hospital, Denpasar. Samples were collected using consecutive method and consisted of gout and non-gout patients. Several characteristics (alcohol and purine consumption,medications, blood pressure, body mass index, serum uric acid level, and serum creatinine) in both groups were collected and compared. Family members (fi rstdegree relatives) of patients in each group were also recruited and had their serum uric acid level measured and compared.Results: A total of 46 patients and 116 family members (23 patients and 58 family members in each group) were enrolled. Among gout patients, there was signifi cantlyhigher prevalence of hyperuricemia, serum uric acid level, blood pressure, and serum creatinine; and lower creatinine clearance compared with the non-gout patients. There was signifi cantly higher prevalence of hyperuricemia among families of gout patients comparedwith families of non-gout patients (60.3 vs. 29.3%, respectively; p = 0.001), with a prevalence ratio of 2.06. Mean serum uric acid level of the family members of gout patients were also signifi cantly higher than the family members of non-gout patients (7.24 (SD 1.74) vs. 5.92 (SD 1.63) mg/dL, respectively; p = 0.000).Conclusion: Among Balinese people in this study, significantly higher prevalence of hyperuricemia and mean serum uric acid level was observed in families of gout patients compared with families of non-gout patients.
CASE REPORT : OSTEOARTHRITIS Putu Imayati; Gede Kambayana
E-Jurnal Medika Udayana vol 2 no 7 (2013):e-jurnal medika udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.348 KB)

Abstract

Osteoarthritis is a degenerative joint disease in which the affected joint is usually the large joint and unilateral. Prevalence of osteoarthritis in Indonesia, 15.5% in men and 12.7% in women, where the incidence is increasing with age. Osteoarthritis is more common an idiopathic disease or unknown cause although there is also a secondary cause such as trauma, infection, neurological or metabolic disorders. The usual complaints that perceived by osteoarthritis patients is pain in the affected joint, especially after the load on the joint. Therapy in osteoarthritis is usually symptomatic, which include the control of risk factors, physiotherapy and pharmacological.
Korelasi Kadar Serum Leptin dengan Aterosklerosis pada Pasien Systemic Lupus Erythematosus Wanita Manaek, Andi; Kambayana, Gede
Jurnal Penyakit Dalam Udayana Vol 1 No 1 (2017): JPD Vol. 1 No.1 2017
Publisher : PAPDI BALI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (685.195 KB)

Abstract

Penyakit kardiovaskular adalah penyebab kematian tertinggi di dunia. SLE diduga berkontribusi kuat mempercepat timbulnya aterosklerosis. Baru-baru ini, banyak bukti ditemukan berhubung dengan efek hormon pada sistem imun termasuk efeknya pada penyakit autoimun. Leptin dikenal sebagai hormon yang menyerupai sitokin dengan aksi pleiotropik dalam memodulasi respon imun. Penelitian yang dilakukan sebelumnya mendapatkan level leptin yang tinggi pada pasien SLE dengan plak aterosklerosis namun berkorelasi lemah dengan carotid Intima Media Thickness (cIMT). Tujuan penelitian ini yaitu untuk mengetahui korelasi serum leptin dengan aterosklerosis pada pasien SLE. Penelitian dilakukan dengan disain analitik potong lintang. Pengambilan sampel dilakukan dengan metode simple sampling. Konsentrasi serum leptin diperiksa dengan menggunakan metode ELISA dan aterosklerosis diperiksa dengan mesin Duplex carotid-intima Doppler Ultrasound oleh satu orang dokter spesialis radiologi. Analisis statistik menggunakan uji korelasi Spearman. Tingkat kemaknaan jika p < 0,05. Sebanyak 54 orang pasien SLE wanita diikutkan dalam penelitian. Rerata kadar serum leptin  adalah 203,83 ± 179,06 ng/ml. Pada pasien didapatkan rerata CIMT adalah 0,48 ± 0,12 mm dengan frekuensi yang mendapat plak 5,5% dan tidak plak 92,7%. Terdapat korelasi lemah antara kadar serum leptin dengan aterosklerosis dalam hal ini yaitu CIMT (r = 0,028; p = 0,843) dan plak (r = 0,008; p = 0,955), tetapi secara statistik tidak bermakna (p < 0,05). Pada penelitian ini tidak didapatkan korelasi antara kadar serum leptin dengan aterosklerosis pada pasien SLE wanita.
Hubungan Konsumsi Purin Tinggi Dengan Hiperurisemia: Suatu Penelitian Potong Lintang Pada Penduduk Suku Bali di Kota Denpasar Indrawan, IGNM Budiana; Kambayana, Gede; Putra, Tjokorda Raka
Jurnal Penyakit Dalam Udayana Vol 1 No 2 (2017): Vol. 1 No. 2 (2017) June-December 2017
Publisher : PAPDI BALI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (349.298 KB)

Abstract

Latar Belakang: Hiperusemia adalah istilah yang menggambarkan kadar asam urat darah di atas normal. Konsumsi purin tinggi merupakan salah satu faktor yang erat kaitannya dengan hiperurisemia. Tujuan: Penelitian ini bertujuan untuk mengetahui adanya hubungan konsumsi purin tinggi dengan hiperurisemia pada penduduk suku Bali di kota Denpasar. Metode: Penelitian ini adalah studi potong lintang analitik yang dilakukan pada bulan Juli sampai dengan September 2004. Populasi pada penelitian ini adalah penduduk suku Bali yang bertempat tinggal di Kota Denpasar. Sampel ditentukan dengan cara stratified random sampling. Penilaian konsumsi purin dilakukan dengan semi quantitative food frequency questionnaire. Analisis dilakukan dengan tabulasi silang dan regresi logistik. Hasil: Penelitian ini melibatkan 302 orang sampel yang memenuhi kriteria inklusi dengan rata-rata umur 43,35 ± 16,72 tahun yang terdiri dari 137 (45,4%) laki-laki dan 165 (54,6%) perempuan. Didapatkan prevalensi obesitas 22,51% dan prevalensi hiperurisemia 18,2%. Didapatkan hubungan yang bermakna antara konsumsi purin tinggi (RP 13,27; IK 95% 6,79-25,88; p < 0,001) dan obesitas (RP 3,32; IK 95% 2,11-5,23; p < 0,001) dengan hiperurisemia. Pada analisis multivariat didapatkan faktor risiko independen hiperurisemia adalah konsumi purin tinggi (OR 26,72; IK 95% 11,69-61,04; p < 0,001) dan obesitas ( OR 4,06; IK 95% 1,81-9,12; p = 0,001). Simpulan: Terdapat hubungan yang bermakna antara konsumsi purin tinggi dengan hiperurisemia pada penduduk suku Bali di kota Denpasar.
Kadar interleukin-17 (IL-17) serum berkorelasi dengan rasio receptor activator of NF-κB ligand/osteoprotegerin (RANKL/OPG) pada penderita Sistemik Lupus Eritematosus Tonny, Tonny; Kambayana, Gede; Putra, Tjokorda Raka; Kurniari, Pande Ketut
Jurnal Penyakit Dalam Udayana Vol 2 No 1 (2018): Vol 2 No 1 (2018) January-June 2018
Publisher : PAPDI BALI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.652 KB)

Abstract

Latar belakang : Proses inflamasi berperan penting dalam patogenesis SLE. Proses inflamasi yang terjadi pada penderita SLE juga akan mempengaruhi diferensiasi osteoklas dan osteoblast. Interleukin-17 (IL-17) merupakan mediator pro-inflamasi yang dihasilkan akibat proses inflamasi sistemik. Peningkatan kadar sitokin pro-inflamasi diketahui mengakibatkan perubahan regulasi RANKL, yang selanjutnya akan mempengaruhi osteoprotegerin (OPG). Peningkatan kadar sitokin pro-inflamasi pada penderita SLE dapat mengakibatkan ketidakseimbangan RANKL/OPG. Tujuan : Mengetahui korelasi antara kadar IL-17 serum dengan rasio RANKL/OPG pada penderita SLE. Metode : Penelitian ini merupakan studi observasional analitik potong lintang yang dilakukan di poliklinik dan bangsal rawat inap. Penyakit Dalam RSUP Sanglah Denpasar, Bali, Indonesia dari bulan Januari-Maret 2018. Penderita SLE berjenis kelamin wanita yang berusia lebih dari 18 tahun dan belum mengalami menopause serta bersedia mengikuti penelitian dengan menandatangani informed consent diikutsertakan dalam penelitian. Kadar IL-17 serum diperiksa dengan menggunakan metode high sensitivity ELISA (Enzyme-linked immunosorbent assay). RANKL diukur menggunakan metode Human sRANKL (TOTAL) ELISA, sedangkan OPG diukur menggunakan metode Human Osteoprotegerin ELISA. Rasio RANKL/OPG didapatkan dari perbandingan antara kadar RANKL dan OPG. Hasil : Penelitian ini melibatkan 68 subyek penelitian. Median umur subyek penelitian yaitu 31,32 (17-54). Kadar IL-17 dan rasio RANKL/OPG pada seluruh subyek yaitu 0,435 (0,23-30,65) dan 70,18 (4,98-1060,46). Didapatkan korelasi yang bermakna antara kadar IL-17 dan rasio RANKL/OPG dengan p=0,010. Dari analisis multivariat didapatkan bahwa kadar IL-17 berkorelasi dengan rasio RANKL/OPG (B=6,554, SE(B)=2,686, p=0,018). Simpulan : Pada penelitian ini terdapat korelasi antara kadar IL-17 serum dengan rasio RANKL/OPG pada penderita SLE.
CASE REPORT : OSTEOARTHRITIS Putu Imayati; Gede Kambayana
E-Jurnal Medika Udayana vol 3 no 2 (2014):e-jurnal medika udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (115.579 KB)

Abstract

Osteoarthritis is a degenerative joint disease in which the affected joint is usually the largejoint and unilateral. Prevalence of osteoarthritis in Indonesia, 15.5% in men and 12.7% inwomen, where the incidence is increasing with age. Osteoarthritis is more common anidiopathic disease or unknown cause although there is also a secondary cause such astrauma, infection, neurological or metabolic disorders. The usual complaints  that perceivedby osteoarthritis patients is pain in the affected joint, especially after the load on the joint.Therapy in osteoarthritis is usually symptomatic, which include the control of risk factors,physiotherapy and pharmacological.
Co-Authors Adnyani, Ni Made Dwi Ali Djamhuri Andriyasa, Andriyasa Anna Ariane Awalia Awalia Dwi Budi Darmawati Faisal Parlindungan Harry Isbagio I K Rina I Nyoman Suarjana IA Ratih Wulansari Manuaba Ida Bagus Aditya Nugraha IGN Eka Imbawan Indrawan, IGNM Budiana Kurniari, Pande Laniyati Hamijoyo Manaek, Andi Nugraha, I.B. Aditya Pande Ketut Kurniari Prisilia, Ni Ketut Donna Putra, T R Putra, Tjokorda Raka Putu Imayati Rakhma Yanti Hellmi Rudy Hidayat Tjokorda Raka Putra Tonny, Tonny Yuliandari KK, Cok Istri