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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Indonesian Journal of Pharmacology and Therapy
Gumilang, Rizki Amalia
Academic Hospital, Universitas Gadjah Mada/ Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Resistin associated with higher cardiovascular events in intermediate grace score of acute coronary syndrome Rizki Amalia Gumilang; Nahar Taufiq; Budi Yuli Setianto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 3 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (294.875 KB) | DOI: 10.19106/JMedSci005303202105

Abstract

Previous studies revealed that inflammatory biomarkers have a role in the clinical outcomes of acute coronary syndromes (ACS) and also in prediction of cardiovascular events using GRACE score. Resistin, a recently identified inflammatory biomarker, also has a role in clinical outcomes of ACS but its role related to GRACE score risk stratification is unknown. Three risk stratifications of ACS based on GRACE scores were used i.e. low, intermediate, and high.  Some studies reported that inflammatory biomarkers have a role in cardiovascular events of patients with low risk GRACE scores, but their role in the patients with intermediate risk still needs to be elucidated. This study aimed to investigate the role of resistin in cardiovascular events of ACS patients with intermediate risk GRACE score. This was an observational study using a cross-sectional design involving sixty-three patients with ACS who fulfilled the inclusion and exclusion criteria. Blood samples were drawn 24 h after onset. Resistin level was analyzed and classified according to its median values. The cardiovascular event was defined as mortality, ischemic events, acute heart failure or arrhythmia during hospitalization. The result showed that cardiovascular events were significantly higher in patients with resistin levels higher than median i.e. 23.8% compared to those with resistin levels similar or lower than median i.e. 11.1% (OR 3.348, 95%CI: 1.125-10.007 p=0.027). It can be concluded high resistin level is associated with an increase of cardiovascular events of ACS with intermediate risk GRACE score.
Co-Authors Anggoro Budi Hartopo Anis Fuad Anwar Santoso Budi Yuli Setianto Deva Bachtiar Gharini, Putrika Prastuti Ratna Jarir At Thobari Luhur Pribadi Lukman Ade Chandra Nahar Taufiq Orisativa Kokasih Pompini Agustina Sitompul Shofuro Hasana Togi Junice Hutadjulu Tri Asti Isnariani Umi Sa'adatun Nikmah Vita Arfiana Nurul Fatimah