<![CDATA[Objective: To compare the diagnostic value of IGFBP-1 and combined
IGFBP-1-AFP rapid tests in diagnosing premature rupture of
membranes (PROM).
Method: This study was conducted in Dr. Soetomo Hospital in Surabaya
from July to November 2013. The subjects were 52 pregnant
women with presumed PROM diagnosis, which was recorded by
clinical data and sampling of vaginal discharge swab. The diagnostic
value was obtained by comparing the results of IGFBP-1 and combinated
IGFBP-1-AFP rapid tests by standard PROM examination
namely vaginal pooling, litmus paper test and ferning test.
Result: A difference between the diagnostic value of IGFBP-1 and
combined IGFBP-1-AFP rapid tests in diagnosing PROM was
shown, where the sensitivity and specificity of IGFBP-1 rapid test was
85% and 95%, compared to combined IGFBP-1-AFP rapid test,
which was 91% and 95%. The correlation coefficient of combined
IGFBP-1-AFP rapid test with standard PROM examination
(r=0.841, p=0.000) was higher than the correlation coefficient of
IGFBP-1-AFP rapid test with standard PROM examination
(r=0.772, p=0.000).
Conclusion: Combined IGFBP-1-AFP rapid test has a better diagnostic
value than IGFBP-1 rapid test alone.
Keywords: combined IGFBP-1-AFP, IGFBP-1, PROM]]>
