Solvent extraction of dog rose seed was conducted to establish best operation conditions for future researches. Extraction variables were temperature, solvent type and seed to solvent ratio. The best extraction conditions at laboratory scale were investigated applying Box-Behnken design (BBD) using response surface methodology (RSM). The highest extract yields were obtained 6.93 % by isopropanol at the optimum conditions a seed to solvent ratio of 3 and temperature range of 50-55 0C. Results of experimental trials confirm of the results of predicted conditions.