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The Effectivenes of Red Rice to Decrease Total Cholesterol in Type 2 DM Patients Wydi Ulfa Pradini; Ancah Caesarina Novi Marchianti; Rini Riyanti
Journal of Agromedicine and Medical Sciences Vol 3 No 1 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i1.4091


Diabetes mellitus (DM) is a group of metabolic diseases with hyperglycemia characteristic that happens because anomaly of insulin secretion or insulin activity. Insulin deficiency in type 2 DM caused dislipidemia. Red rice are contain fiber, essential fatty acid and Gamma Amino Butiric Acid (GABA). This research intended to know the effectiveness of red rice to decrease total cholesterol levels of patient with type 2 DM. Clinical test with quasi experimental and research design non randomized control-group pretest-postest design was used for the research method. Total samples of this research are 36 samples. The treated group was given the red rice during 6 days on breakfast and dinner, while the control group did not have any intervention. The research showed that average cholesterol levels in the beginning and finale of treated group was 235,69 mg/dL and 198,56 mg/dL, while average cholesterol levels in the beginning and finale of control group was 235,72 mg/dL and 256,50 mg/dL. From this research, red rice has effective to decrease  total cholesterol levels of patients with type 2 DM.Keywords: Diabetes mellitus, Red Rice, Cholesterol total levels
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Worldwide estimates of people living with HumanImmunodeficiency Virus was approximately 32million in 2007 with thousands of people gettinginfected every day therapy (Obirikorang,2012). Globally, 34 million people were living withhuman immunodeficiency virus (HIV) at the end of2011 (Chen, 2013). Most people living withHIV are from developing countries with less than5% receiving antiretroviral therapy (, 2012).A CD4 count is a laboratory test that measures thenumber of CD4 T lymphocytes (CD4 cells) in asample of blood. In HIV patients, it is the mostimportant laboratory indicator of how well theimmune system is working and the strongestpredictor of HIV progression. Once a person isinfected with HIV, the virus begins to attack anddestroy the CD4 cells of the person’s immunesystem. HIV uses the CD4 cells to multiply andspread throughout the body. This is the HIV lifecycle.The associated immune deficiency in humanimmunodeficiency virus (HIV) patients leading toinfection by opportunistic pathogen is ascribed todepletion of CD4. CD4 count can therefore beregarded as the accurate measurement of therobustness and functionality of the immunecapability to protect the body against generalinfection. CD4 T lymphocyte cell depletion is one ofthe hallmarks of progression of HIV infection and amajor indicator of the stage of the disease in HIVinfected individuals. World Health Organizationrecommended that most treatment initiationdecisions be guided by CD4 measurement andclinical staging.AIDS is the stage of HIV infection that occurs whenthe immune system is badly damaged and it isbecome vulnerable to opportunistic infections.When the number of your CD4 cells falls below 200cells/mm3, these are considered to haveprogressed to AIDS. (In a healthy immune system,CD4 counts are between 500 and 1,600cells/mm3.)The initiation of antiretroviral therapy is based onCD4 counts of less than 350 cells/mm3 according tothe World Health Organization (WHO) and Centrefor Disease Control (CDC). The determination ofCD4 count however in resource-limited localities isdifficult.In April 2002, the World Health Organization(WHO) suggested that total lymphocyte count(TLC) could serve as a surrogate for CD4+cell countbecause TLC is easily obtained from routinecomplete blood cell counts by multiplying thepercentage of lymphocytes by the white-blood-cellcount (Chen, 2013).Total lymphocyte count(TLC) is a derived immunological marker calculatedfrom white blood cell count and relativelymphocyte count. For instance, if a patient has atotal white blood cell count of 10.0 × 10⁹/L andrelative lymphocyte count of 30% obtained fromdifferential leukocyte count, total lymphocytecount of such patient would be 3 × 10⁹/L.The aim of this study was therefore to ascertainexisting relationships between CD4 count and TLCand to further ascertain if TLC could be used as asurrogate markerfor CD4 counts.
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i2.847


Urinary tract infection diagnosis is based on urine culture, taken from a midstream collection in the morning. Obtaining samplesin this manner is difficult in children less than 3 years. In children less than 3 years, urine is obtained by urine collectors. Using urinecollectors may cause discomfort, and the possibility that the urine collectors may not adhere resulting in contamination. (1) Developinga practical method for urine sample collection. (2) Comparing culture from diapers and urine collectors samples. (3) Knowing the limittime for using diapers acceptable for urine culture. Urine samples were obtained from 20 children less than 3 years, using urine collectorsand diapers used for 1 hour, 2 hours and 3 hours and then cultured. Majority of the urine culture from diapers used for 1 hour and 2hours showed the same result with the urine culture from urine collectors. Contamination was found in the urine culture result fromdiapers used for 3 hours. Urine samples from diapers used for 1 hour and 2 hours can be used as samples for urine culture. The techniqueis easy and can be done in children less than 3 years.
The Correlation between Ferritin Levels and Glutation (GSH) Levels in Major Beta Thalassemia Patient at dr. Soebandi Jember Hospital Amalia Nur Zahra; Rini Riyanti; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i1.6322


Repeated blood transfusions in patient with Major Beta Thalassemia leads to iron overload marks by the increased of serum ferritin levels. Free iron caused the change of H2O2 to oxidants by fenton reaction and caused oxidative stress. These oxidants will be counteracted by GSH as antioxidants. The purpose of this study was to investigate the correlation between ferritin levels with GSH in patients with major beta thalassemia in RSD dr. Soebandi hospital Jember. The samples of this study are fifteen (15) patients age 1-18 years who were regularly transfused. Serum ferritin levels were measured by Enzyme-Linked Fluorescent Immuno Assay (ELFA) and plasma GSH levels were measured by Ellman method. Data was analyzed using Pearson correlation test. Serum feritin levels were increased in Major Beta Thalassemia children with average of 3540,46 ± 3925,37 ng/mL. The mean of GSH is 10,46 ± 2,58 µmol. We found significant and negative correlation between serum ferritin and GSH with p value=0,000 and r=-0,951 in Major beta thalassemia patient at RSD dr. Soebandi Jember. Keywords: Thalassemia, Oxidative stress, Feritin, GSH
The Activity of Cainito Leaves Ethanol Extract (Chrysophyllum cainito L.) on Wistar’s Total Erythrocites Induced Cyclophosphamide Heri Puguh Widodo; Ika Rahmawati Sutejo; Rini Riyanti
Journal of Agromedicine and Medical Sciences Vol 6 No 2 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i2.7588


One of the commonly used chemotherapy drugs is cyclophosphamide. However, the use of cyclophosphamide can provide various toxic effects. The most common toxic effect of cyclophosphamide is bone marrow suppression with anemia as one of its markers. The antioxidant content of cainito leaf potentially increase the production of blood cells, especially erythrocytes. The aims of this study is determining the effectiveness of the cainito leaf ethanol extract against cyclophosphamide induced mouse erythrocyte count in vivo. A sample of 20 male wistar rats was divided into five groups; normal group, negative control group, and three groups of ethanol extract of cainito leaf with dose 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW were administered for one week followed by intraperitoneal cyclophosphamide with dose 50 mg/kgBW as much as one time. One Way Anova Test result showed a significance of 0.015 (p<0.05). However, the LSD test results showed no significant different results between the negative control group and the treatment group. The conclusion was that there was no difference in the amount of erythrocytes in mice given only cyclophosphamide with previous rats given cainito extract.
Effects of Herbal Forte Rice as Replacement of Carbohydrate to Insulin Resistance in Patients with Type 2 Diabetes in Sumbersari Health Center Jember Dina Faizatur Rahmah; Ancah Caesarina Novi Marchianti; Rini Riyanti
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5064


The population of type 2 diabetes mellitus sufferer continuously increases due to the increase of insulin resistance characterised by the rise of the secretion insulin. Insulin resistance is affected by several factors such as the lack of physical activity, obesity, and unhealthy diet. One of the characteristics of the unhealthy diet is the high consumption of carbohydrates.Whereas Indonesian prefers to have carbohydrate sources from food which has high glycemic index such as rice so thatit makes the glucose in the blood increased rapidly. This condition causes more and faster insulin secretion and can affect insulin resistance. The purpose of this study is to know the effectiveness of herbal forte rice as a substitute of the main carbohydrate in the state of hyperinsulinemia suffered by 15 patients of type 2 diabetes mellitus in Puskesmas (community health center) Sumbersari Jember. This study is a clinical trial with a quasi experimental method and crossover design. In this study, the sample is interviewed by characteristics (age, gender) and the early consumption patterns using 24-hour food recall three times at different times. Samples acted as a control group once the experimental group. The control group did not receive any treatment, while the experimental group received the herbal forte rice as much as 100 grams for 7 consecutive days in the morning (at 06.30 am). After washing out period for 9 days, experimental group switched into control group. At the end of the period (7 days), data of fasting blood glucose and fasting insulin were collected then counted by HOMA-IR formula. The result of the study based on the paired t test p=0.001 in comparison to the state of the control and experimental group. The conclusion of this study is there is a changing state of insulin resistance with the replacement of food based on glycemic index.