From 1984 until the present, the National Library of Indonesia has managed the country’s International Standard Book Number (ISBN) system. In 2017, the ISBN online service launched a single account, or access, for which each publisher could register. However, various problems still arise, among them the usability within the system. By collecting responses from 757 respondents who work in publishing companies, this study analyses the relationship between demographic characteristics and a user experience component: usability in the ISBN Online service. The study found five significant relationships. Among other demographic factors, it found that gender is effective at classifying and differentiating usability variable in the ISBN Online service.