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Ruslan Effendy

Fakultas Kedokteran Gigi Universitas Airlangga, Surabaya

Author-ID : 3573885

Dentistry

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EKSPRESI TGF-B DAN MMP-1 PADA PERIODONTITIS APIKALIS KRONIS AKIBAT INDUKSI BAKTERI ENTEROCOCCUS FAECALIS TIKUS WISTAR Tamara Yuanita; Hadriany Hotmaria; Ruslan Effendy; Ketut Suardita
Conservative Dentistry Journal Vol. 7 No. 2 (2017): July - December
Publisher : Universitas Airlangga

Background. The main etiology of endodontic treatment failure is caused by bacteries that stay in the root canal. E.faecalis is a bactery that is found as an etiology of endodontic treatment failure. Cell wall of this bacteria is containing Lipoteichoic acid (LTA). LTA can penetrate into the periradicular tissue, act as endotoxin in host and cause periradicular inflammation and destruction. It occurs due to the capability of TGF-ß to enhance the proliferation collagen and MMP-1 to stop the collagen formation. The ability of enterococcus faecalis in enhancing inflamation process cause host can not reach the homeostasis phase and performing an even bigger tissue damage. Purpose. The aim of this study is to know about the expression of of TGF-ß and MMP-1 during the periapical tissue damage due to induction of E.faecalis. Method. This study used laboratory experimental with the post test only control group design. A total of 27 male rats were randomly divided into 3 main groups. Group A (negative control) : every tooth was’nt induced by anything. Group B ( positive control): every tooth was induced only by sterile BHIb and closed by GIC Fuji II as the final restoration. Group C (: every tooth was induced by 10 μl BHI-b E.faecalis ATCC212(106 CFU), and closed by GIC Fuji II as the final restoration. The animals were sacrificed after 21 days and prepared for histological examination of tissue damage, then we did the immunohistochemistry followed by calculation on the light microscope. Result. The analysis revealed that the expression of MMP-1 increased significantly in group C when E.faecalis was induced. When expression of TGF-ß decreaced significantly in group C rather than group B. Conclusion. From this study we know that the expression of TGF-ß and MMP-1 are make opposite pathway due to chronic apical periodontitis that induced by E.faecalis.

The effect of glycerin on the surface hardness and roughness of nanofill composite Diana Zakiyah; Ruslan Effendy; Edhie Arif Prasetyo
Conservative Dentistry Journal Vol. 8 No. 2 (2018): July - December
Publisher : Universitas Airlangga

Background: Present research studied the surface hardness and roughness dependence on polymerization. Polymerization of composites occurs through chain reaction that is induced by free radicals. Oxygen in the air decreases the excitability of the photo initiator, causing polymerization interference. Oxygen inhibition layer (OIL) is formed on the surface. OIL can be reduced by curing the composite through by application of glycerin to the surface. Purpose: To determine the effect of glycerin on the surface hardness and roughness of nanofill composite. Material and Methods: 64 specimens of composite (Z350 XT, 3M) were prepared using a disc-shaped acrylic. The groups were divided into group A surface hardness (N=32) and group B surface roughness (N=32). Group A1, the specimen was coated with glycerin and light cured for 20 s and group A2, the specimen was exposed to air and light cured for 20 s. Group B1 was coated with glycerin and light cured for 20 s and Group B2 was exposed to air and light cured for 20 s. The specimens were stored in distilled water for 24 h at 370. Measuring with Vickers and surface roughness tester and. Data were statistically analyzed using Mean-whitney U Test. Results: There were statiscally significant difference between the surface hardness and roughness of nanofill composite coated with glycerin and without glycerin (p<0,05) Conclusion: The surface hardness of nanofill composite resin coated with glycerin is higher than composite without glycerin and the surface roughness of nanofill composite resin coated with glycerin is lower than composite without glycerin

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Journal : Conservative Dentistry Journal