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Role of Risk Factors in the Incidence of Multidrug-Resistant Tuberculosis Khairani, Alya Putri; Santoso, Prayudi; Setiawati, Elsa Pudji
International Journal of Integrated Health Sciences Vol 5, No 2 (2017)
Publisher : International Journal of Integrated Health Sciences

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Objective: To determine the risk factors that played roles in the incidence of multidrug-resistant tuberculosis (MDR-TB) in such patients. Multidrug-Resistant Tuberculosis is a form of tuberculosis caused by Mycobacterium tuberculosis that is resistant to at least isoniazid and rifampicin.Methods: This was a case control study to compare MDR-TB to non-MDR-TB pulmonary tuberculosis outpatients in Dr. Hasan Sadikin General Hospital, Bandung on Augustâ€“September 2014. Fifty MDR-TB outpatients were included as the cases and 50 non-MDR-TB outpatients as controls. Data was collected by questionnaires and patientâ€™s registration forms. Bivariate and multivariate analyses were performed using chi-square test and multiple logistic regression test, with p<0.05 considered significant. Results: From bivariate analysis, number of previous tuberculosis treatments, regularity of previous treatment, and burden of cost were significant risk factors for developing MDR-TB (p<0.05); while from multivariate analysis, number of previous TB treatments was the only risk factor that played a significant role in the incidence of MDR-TB (OR 24.128 95% CI 6.771-85,976). Conclusions: Patients and medication factors are risk factors that play roles in the incidence of MDR-TB. The significant risk factor is the number of previous TB treatment. Keywords: Multidrug-resistant tuberculosis, resistance, risk factors, tuberculosisÂ DOI:Â 10.15850/ijihs.v5n2.991

Effect of Treadmill Exercise Using 80% Intensity of Six Minute Walk Test on Walking Distance and Quality of Life in Moderate Stage Chronic Obstructive Pulmonary Disease Patients Arisanti, Farida; Vitriana, Vitriana; Santoso, Prayudi
Majalah Kedokteran Bandung Vol 48, No 2 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Skeletal muscle dysfunction poses as one of the systemic manifestation of chronic obstructive pulmonary disease (COPD) in the impact of inactivity and deconditioning from early fatigue to the end of declining quality of life (QoL). Giving pulmonary rehabilitation program of treadmill exercise will overcome the problem, but standard method for moderate stage of COPD is not yet available. This study aimed to evaluate the effect of treadmill exercise using 80% intensity of six minute walk test on walking distance and QoL in moderate stage COPD in order to overcome muscle dysfunction. Samples were taken from Physical Medicine and Rehabilitation and Respirology subdivision of Internal Medicine outpatient clinic of Dr. Hasan Sadikin General Hospital Bandung, from March 2012â€“April 2013. Data analysis was tested using t-test for comparison of two independent mean data. Otherwise, non parametric test of Mann Whitney and Wilcoxon Match Pair test. Thirty three subjects of moderate stage COPD were divided into 2 groups (intervention and control). Intervention group received treadmill exercise with 80% intensity from preliminary 6MWT for 30â€“60 minutes/session, 3 session/week for 6 weeks. Significant increase on walking distance was found in intervention group (70.66 m) compared to control group (7.43 m) after 6 weeks (pâ‰¤0.05). QoL using St. George Respiratory Questionnaire (SGRQ) showed significant decrease in intervention group for all components in the end of 6 weeks (total p=0.0038, symptoms p=0.0162, activities p=0.0043 and impact p=0.0057, pâ‰¤0.05). Eighty percent intensity of 6MWT in treadmill exercise for 6 weeks was well tolerated and could overcome skeletal muscle dysfunction in moderate stage COPD. It also revealed higher values in aerobic capacity and QoL compared to previous studies. In conclusion, treadmill exercise using 80% intensity of 6MWT provides further walking distance and higher QoL compared to controlÂ in moderate stage COPD. [MKB. 2016;48(2):105â€“11]Key words: Moderate stage COPD, quality of life, treadmill exercise, 6MWDPengaruh Latihan Erobik Menggunakan Treadmill dengan Intensitas 80% Uji Jalan 6 Menit terhadap Jarak Tempuh dan Kualitas Hidup Pasien PPOK Derajat SedangDisfungsi otot rangka merupakan salah satu manifestasi sistemik penyakit paru obstruktif kronik (PPOK), menyebabkan penderita mengalami inaktivitas dan dekondisi akibat kelelahan dini sehingga menurunkan kualitas hidupnya. Latihan erobik menggunakan treadmill merupakan modalitas dalam rehabilitasi PPOK untuk mengatasinya, namun hingga saat ini belum ada metode baku pada PPOK derajat sedang. Penelitian ini bertujuan menilai pengaruh latihan erobik menggunakan treadmill dengan intensitas 80% uji jalan 6 menit terhadap jarak tempuh dan kualitas hidup pada pasien PPOK derajat sedang. Penelitian ini dilakukan di Departemen Ilmu Kedokteran Fisik dan Rehabilitasi Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung periode Maret 2012â€“April 2013. Naracoba berjumlah 33 orang, dibagi menjadi kelompok kontrol dan perlakuan. Latihan dilakukan dengan intensitas 80% kecepatan uji jalan 6 menit, 30â€“60 menit/sesi, 3x/minggu selama 6 minggu. Terjadi peningkatan bermakna jarak tempuh (pâ‰¤0,05) dan penurunan nilai St. George Respiratory Questionnaire (SGRQ) di seluruh komponennya (total, dampak, gejala dan aktivitas, pâ‰¤0,05) kelompok perlakuan dibanding dengan kontrol setelah 6 minggu latihan. Latihan erobik menggunakan treadmill dengan intensitas 80% kecepatan uji jalan 6 menit selama 6 minggu ditoleransi dengan baik dan dapat memperbaiki disfungsi otot rangka pada pasien PPOK derajat sedang. Simpulan, latihan erobik menggunakan treadmill dengan intensitas 80% dari uji jalan 6 menit memberikan peningkatan jarak tempuh dan kualitas hidup dibanding dengan kontrol pada PPOK derajat sedang. [MKB. 2016;48(2):105â€“11]Kata kunci: Jarak tempuh uji jalan 6 menit, kualitas hidup, latihan treadmill, PPOK derajat sedang

Comorbidities of Chronic Obstructive Pulmonary Disease Patients at Respirology and Critical Care Outpatient Clinic Dr. Hasan Sadikin General Hospital, Bandung, Indonesia Suhendro, Adrian Sebastian; Santoso, Prayudi; Riswari, Silvita Fitri
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

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Background: Chronic obstructive pulmonary disease (COPD) is a chronic disease that becomes one of the leading causes of death in the world. The COPD is usually accompanied by comorbidities that impact prognosis and increase patientsâ expenses. However, the comorbidities of COPD patients have not yet to be known in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. This study was aimed to determine the frequency, type and number of comorbidities accompanying COPD.Methods: This study was a retrospective, cross-sectional study at the respirology and critical care outpatient clinic of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia in 2012. Data were obtained from medical records of patients diagnosed with COPD and had an obstructive pulmonary function test result. Sampling technique in this study was total sampling. Data were classified by age, gender, smoking history and severity of disease and were analyzed to determine the frequency, type and number of comorbidities accompanying COPD. Results: Thirty eight COPD patients with obstructive pulmonary function test results were analyzed. It consists of 31 males and 7 females with age ranged between 43â82 years and median age of 64 years. Severe obstruction was found in 15 of 38 patients. Comorbidities were found in 26 patients, and 2 patients had up to four comorbidities. The most common comorbidity was hypertension (9 of 38).Conclusions: The majority of COPD patients had comorbidities and the most frequent comorbidity was hypertension. [AMJ. 2017;4(1):30â5]DOI:Â 10.15850/amj.v4n1.1016

DIFERENSIASI ASMA ATOPIK DENGAN NONATOPIK PADA PASIEN RAWAT JALAN DI KLINIK PARU-ASMA Dahlan, Zul; Santoso, Prayudi
Majalah Kedokteran Bandung Vol 45, No 2 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Terdapat kesulitan penatalaksanaan asma karena mekanisme asma yang kurang jelas dan terdapat berbagai fenotipe asma yang bersifat individual memerlukan terapi pendekatan individual. Salah satu fenotipe asma adalah asma atopik dan nonatopik yang secara klinis susah dibedakan. Penelitian bersifat deskriptif analitik, rancangan potong lintang dilakukan untuk melihat perbedaan karakteristik asma atopik dengan nonatopik. Subjek penelitian penderita asma baru yang berobat jalan di klinik Paru Asma An-Nur Bandung tahun 2007?2008. Pada pasien tersebut dilakukan pemeriksaan nilai total IgE, spirometri, dan tes tusuk kulit. Terdapat 198 pasien asma terdiri atas 149 (75,3%) pasien atopik dan 49 (24,7%) nonatopik. Median usia pasien nonatopik adalah 39 tahun dan atopik 34 tahun (p=0,039). Terdapat perbedaan bermakna keluhan sesak napas kelompok atopik (68,5%) dan nonatopik (44,9%) (p=0,003), tidak bermakna pada pemeriksaan spirometri. Riwayat atopik pasien sendiri terdapat pada kelompok asma atopik (p=0,011), bermakna pada rinitis (81,2 vs 61,2 OR 2,7) dan urtikaria (14,8 vs 4,1 OR 4,0). Asma nonatopik tidak lebih berat dibandingkan dengan atopik yang diketahui dari pemeriksaan persentase forced expiratory volume first second (FEV1). Pada pasien rinitis dengan urtikaria, risiko mendapatkan asma atopik lebih besar. Simpulan, tidak ada perbedaan hasil tes tusuk kulit pada kedua kelompok. Gejala klinis kelompok atopik sesuai dengan positivitas hasil pemeriksaan IgE. Keadaan klinis rinitis dan urtikaria lebih menjuruskan diagnosis ke arah asma atopik dibandingkan dengan gambaran klinis lainnya atau hasil spirometri. [MKB. 2013;45(2):105?11]Kata kunci: Asma atopik, asma nonatopik, IgE, karakteristik klinisDifferentiation of Atopic and Non-Atopic Asthma in Out-Patient Pulmo-Asthma ClinicThere is a difficulty in asthma management regarding to unclear mechanism of asthma, and a variety of asthma phenotypes that individually require individual therapy and approach. The asthmatic phenotype atopic and nonatopic was clinically difficult to distinguish. The study was analytical descriptive with cross-sectional design. The study aim was to explore the differences of atopic and non-atopic asthmatic characteristics. The study subjects were newly asthmatic patients who were out-patients of An-Nur Lung-Asthmatic Clinic, Bandung, in 2007?2008. In patients examined total IgE, spirometry and skin prick test. There were 198 asthmatic patients comprising 149 (75.3%) atopic and 40 (24.7%) non-atopic asthma. The median of the non-atopic age was 39 years, while the atopic was 34 years (p=0.039). There was a significant difference between atopic (68.5%) and non-atopic (44.9%) in complaint of short breath (p=0.003), but non significant in spirometric examination. The history of atopy were present in atopic asthma group (p=0.011), with significance in rhinitis (81.2 vs 61.2 OR=2.7) and urticaria (14.8 vs 4.1 OR=4.0). Non-atopic asthma was not more severe that atopic asthma was known from examination of forced expiratory volume first second (FEV1). Rhinitis patient, having urticaria, have greater risk for atopic asthma. There were no difference in skin prick test results between both groups. The clinical symptoms of atopic group were in line with the positivenes results of IgE examination. Clinical condition of rhinitis and urticaria direct to the diagnosed towards atopic asthma compared than other clinical features or spirometric result. [MKB. 2013;45(2):105?11]Key words: Atopic asthma, clinical characteristics, IgE, non-atopic asthma DOI: http://dx.doi.org/10.15395/mkb.v45n2.112

KORELASI JUMLAH CLUSTER OF DIFFERENTIATION 4 DENGAN JENIS BAKTERI PENYEBAB INFEKSI PARU DARI KULTUR BILASAN BRONKOALVEOLAR PADA PASIEN HUMAN IMMUNODEFICIENCY VIRUS Turbawati, Dewi Kartika; Supriatna, Yana Akhmad; Santoso, Prayudi; Melindah, Melindah
Majalah Kedokteran Bandung Vol 48, No 1 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Infeksi paru bakteri adalah penyebab utama morbiditas dan mortalitas pasien human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). Infeksi HIV menyebabkan disfungsi sistem kekebalan yang dimanifestasikan penurunan jumlah cluster of differentiation 4 (CD4). Tujuan penelitian menentukan hubungan jumlah CD4 dengan jenis bakteri penyebab infeksi paru dari kultur bilasan bronkoalveolar pasien HIV di RS Dr. Hasan Sadikin Bandung. Penelitian analitik observasional dengan rancangan potong lintang. Pengambilan sampel sejak November 2011 sampai Oktober 2013 di Departemen Ilmu Penyakit Dalam RS Dr. Hasan Sadikin Bandung. Subjek 39 orang memenuhi kriteria inklusi, didapatkan usia rata-rata 32 tahun. Jumlah median CD4 18 (rentang, 0?190) sel/mm3. Hasil kultur jenis bakteri batang gram negatif 29/39 sampel dan kokus gram positif 10/39 sampel. Spesies terbanyak Pseudomonas aeruginosa 11/39 sampel, Klebsiella pneumoniae 11/39 sampel dan Streptococcus viridans 10/39 sampel. Analisis statistik berdasarkan point biserial correlation terdapat korelasi lemah (r=0,232) dan tidak bermakna antara CD4 dan jenis bakteri penyebab dengan nilai p=0,209 (p>0,05). Arah korelasi menunjukkan semakin kecil jumlah CD4 semakin besar kemungkinan bakteri batang gram negatif sebagai penyebab infeksi paru. Penelitian ini menunjukkan korelasi lemah antara jumlah CD4 dan jenis bakteri penyebab infeksi paru dari bilasan bronkoalveolar pada pasien infeksi HIV di RS Dr. Hasan Sadikin Bandung. [MKB. 2016;48(1):32?8]Kata kunci: Bilasan bronkoalveolar, human immunodeficiency virus (HIV), infeksi paru bakteri, jumlah CD4Correlation between Cluster of Differentiation 4 Cell Counts and Types of Bacteria Causing Lung Infection from Cultured Washing of Bronchoalveolar Lavage in Human Immunodeficiency Virus PatientsAbstractBacterial lung infection is the leading cause of morbidity and mortality of patients with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). HIV infection causes immune system dysfunction, which is manifested by decreased cluster of differentiation 4 (CD4) cell counts. The purpose of this study was to determine the correlation between CD4 cell counts and the type of bacteria that caused lung infection from cultured washing of bronchoalveolar lavage in HIV patients in Dr. Hasan Sadikin Hospital Bandung. This was an observational analytic study with a cross-sectional design. Subjects were collected from November 2011 to October 2013 in Internal Departement Dr. Hasan Sadikin Hospital Bandung. There were 39 subjects enrolled with the average age of patients was 32 years. The median CD4 cell counts was 18 (range, 0?190) cell/mm3. The type of gram-negative rods bacteria was 29/39 samples and gram-positive cocci was 10/39 samples. Most species were Pseudomonas aeruginosa 11/39 samples, Klebsiella pneumoniae 11/39 samples and Streptococcus viridans 10/39 samples. Statistical analysis based on a point biserial correlation showed weak (r=0.232) and no significant correlation between CD4 cell counts and the type of bacteria (p>0.05). The weak correlation was the smaller the number of CD4 cell counts, the greater possibility of the gram-negative rod bacteria being the cause of the infection. This study concluded that there is only a weak and no correlation between the number of CD4 cell counts and the type of bacteria causing the lung infection obtained from bronchoalveolar lavage in patients with HIV in Dr. Hasan Sadikin Hospital Bandung. [MKB. 2016;48(1):32?8]Key words: Bacterial lung infection, bronchoalveolar lavage, CD4 cell counts, human immunodeficiency virus

Ethionamide Modulates of Thyroid Stimulating Hormone, Thyroxine, and Triiodothyronine Levels in White Ratstimulating Hormone (TSH), Thyroxine (T4), and Triiodothyronine (T3) Serum are potentially modulated Level by Ethionamide in Rats ronny lesmana; Fani Rahma Yenita; Prayudi Santoso; Hanna Goenawan; Arto Yuwono Soeroto; Yuni Susanti Pratiwi; Nova Sylviana; Iwan Setiawan; Vita Murniati Tarawan; Unang Supratman
Jurnal Veteriner Vol 21 No 3 (2020)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Multidrug-Resistant Tuberculosis (MDR-TB) infection is not solely caused serious impact for patient and cause long recovery process. Multidrug-Resistant Tuberculosis needs specific treatment approach using second-line TB drugs. Ethionamide as one of medication used in MDR-TB are known to cause greater side effects compared to the first-line drugs. One of side effect like hypothyroidism is remain unclear. There is limited study about role of ethionamide cause hypothyroidism. In this present study, 24 male, wistar rats were divided into three groups: ethionamide group; positive control positive (propylthiouracil) and negative control group (received distilled water only) and treated accordingly for 12 week. Under ketamine and xylazine anesthesia, blood sample were collected from retroorbital vein at 8 and 12 week, put in EDTA tube and stored -20Ë%C until use. After last sampling, rat were sacrificed using CO2 chamber. Our data showed that thyroid stimulating hormone (TSH) levels in ethionamide group is increased from 8 weeks to 12 weeks significantly, but there is no significant changes in control groups. Thyroxine (T4) levels is trend decreased from 8 weeks to 12 weeks compared to control groups. There is no change of Triiodothyronine (T3) levels. Effect of ethionamide on thyroid hormone (T3 and T4) levels was not prominent and there were no significant changes observed. Interestingly, we observed an increase of TSH level after ethionamide treatment. Taken together, 12 week treatment of ethionamide tablet might potentially modulate thyroid hormone (T3 and T4) levels that is reflected from an increase of TSH levels in the plasmas feed back negative mechanism.

The Effect of Treadmill Aerobic Exercise on Walking Distance, Lung Function and Quality of Life in Tuberculosis Patients Muhamad Ilham; Marina Moeliono; Prayudi Santoso
Indonesian Journal of Physical Medicine & Rehabilitation Vol 4 No 01 (2015): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Objective: To observe the effect of treadmill aerobic exercise on walking distance, lung functionand QoL in lung tuberculosis patients.Methods: It was an interventional study using controlled random sampling with pre- and post- interventionobservation. The study took place at Hasan Sadikin Hospital, Bandung. Subjects were post-category IImedicationpulmonary TB patients with negative AFB conversion, males and females aged 18-60 years,normal BMI (according to Indonesian Ministry of Health 2003), able to comprehend spoken, writtenand signed instructions (mini mental state examination - MMSE 22-30), able to undergo a six-minuteswalking test (6MWT), cooperative and willing to participate in the study. This study analyzed data from30 subjects divided into two groups (interventional vs control group, each 15 subjects). Control groupwas given educational program, breathing techniques and chest- expansion exercises to do at home for6 weeks (3 times a week), whereas the study group received additional aerobic exercise for 6 weeks(walking on a treadmill, 3 times a week, 30-60 minutes per session) with the intensity of 80% of the speeddetermined from the result of the 6MWT. Pre- and post- six weeks, walking distance (6MWT), lungfunction and St. George’s Respiratory Questionnaire (SGRQ) evaluation were obtained from subjects.Results: Walking distance of interventional group (mean 75.53 m, p<0.05) increased significantly after6 weeks. There were also significant difference between two groups in the SGRQ components exceptfor symptoms. Lung functions as shown on FVC and FEV1 increased significantly in interventionalgroup. However, this increase was not confirmed by the change of breathing impairment pattern.Conclusion: The significant difference between the study and the control groups showed that aerobicexercise using treadmill gives better improvement on the quality of life. This fact demonstratesthat exercise program in pulmonary rehabilitation remains the core program to increase functionalcapacity and quality of life.Keywords: lung tuberculosis, aerobic exercise, treadmill, walking distance, quality of life, SGRQ

The Effect of Treadmill Aerobic Exercise on Walking Distance, Lung Function and Quality of Life in Tuberculosis Patients Muhamad Ilham; Marina Moeliono; Prayudi Santoso
Indonesian Journal of Physical Medicine & Rehabilitation Vol 4 No 01 (2015): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Objective: To observe the effect of treadmill aerobic exercise on walking distance, lung functionand QoL in lung tuberculosis patients.Methods: It was an interventional study using controlled random sampling with pre- and post- interventionobservation. The study took place at Hasan Sadikin Hospital, Bandung. Subjects were post-category IImedicationpulmonary TB patients with negative AFB conversion, males and females aged 18-60 years,normal BMI (according to Indonesian Ministry of Health 2003), able to comprehend spoken, writtenand signed instructions (mini mental state examination - MMSE 22-30), able to undergo a six-minuteswalking test (6MWT), cooperative and willing to participate in the study. This study analyzed data from30 subjects divided into two groups (interventional vs control group, each 15 subjects). Control groupwas given educational program, breathing techniques and chest- expansion exercises to do at home for6 weeks (3 times a week), whereas the study group received additional aerobic exercise for 6 weeks(walking on a treadmill, 3 times a week, 30-60 minutes per session) with the intensity of 80% of the speeddetermined from the result of the 6MWT. Pre- and post- six weeks, walking distance (6MWT), lungfunction and St. George’s Respiratory Questionnaire (SGRQ) evaluation were obtained from subjects.Results: Walking distance of interventional group (mean 75.53 m, p<0.05) increased significantly after6 weeks. There were also significant difference between two groups in the SGRQ components exceptfor symptoms. Lung functions as shown on FVC and FEV1 increased significantly in interventionalgroup. However, this increase was not confirmed by the change of breathing impairment pattern.Conclusion: The significant difference between the study and the control groups showed that aerobicexercise using treadmill gives better improvement on the quality of life. This fact demonstratesthat exercise program in pulmonary rehabilitation remains the core program to increase functionalcapacity and quality of life.Keywords: lung tuberculosis, aerobic exercise, treadmill, walking distance, quality of life, SGRQ

Comorbidities of Chronic Obstructive Pulmonary Disease Patients at Respirology and Critical Care Outpatient Clinic Dr. Hasan Sadikin General Hospital, Bandung, Indonesia Adrian Sebastian Suhendro; Prayudi Santoso; Silvita Fitri Riswari
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (545.746 KB)

Background: Chronic obstructive pulmonary disease (COPD) is a chronic disease that becomes one of the leading causes of death in the world. The COPD is usually accompanied by comorbidities that impact prognosis and increase patients’ expenses. However, the comorbidities of COPD patients have not yet to be known in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. This study was aimed to determine the frequency, type and number of comorbidities accompanying COPD.Methods: This study was a retrospective, cross-sectional study at the respirology and critical care outpatient clinic of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia in 2012. Data were obtained from medical records of patients diagnosed with COPD and had an obstructive pulmonary function test result. Sampling technique in this study was total sampling. Data were classified by age, gender, smoking history and severity of disease and were analyzed to determine the frequency, type and number of comorbidities accompanying COPD. Results: Thirty eight COPD patients with obstructive pulmonary function test results were analyzed. It consists of 31 males and 7 females with age ranged between 43–82 years and median age of 64 years. Severe obstruction was found in 15 of 38 patients. Comorbidities were found in 26 patients, and 2 patients had up to four comorbidities. The most common comorbidity was hypertension (9 of 38).Conclusions: The majority of COPD patients had comorbidities and the most frequent comorbidity was hypertension. [AMJ. 2017;4(1):30–5]DOI: 10.15850/amj.v4n1.1016

Association between Malnutrition Inflammation Score and Latent Tuberculosis among Chronic Hemodialysis Patients Ria Bandiara; Lilik Sukesi; Astried Indrasari; Alif Bagus Rakhimullah; Afiatin Afiatin; Prayudi Santoso
International Journal of Integrated Health Sciences Vol 9, No 1 (2021)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v9n1.2370

Objective: To investigate the association of malnutrition with latent tuberculosis (TB) among chronic kidney disease (CKD) patients on hemodialysis (HD).Methods: This was a cross-sectional study conducted at the Hemodiaylisis Unit of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Subjects were patients aged >18 years who had undergone HD twice a week for at least three months. Patients suspected of active tuberculosis (TB), malignancy, or immunocompromised were excluded. Latent TB was diagnosed using the interferon-gamma release assays (IGRA). Malnutrition was defined by a malnutrition inflammation score (MIS) of less than 5. All data including age, sex, CKD etiologies, and laboratory findings were obtained and recorded in a case report form.Results: A total of 120 subjects were involved in this study. Subjects with positive, negative, and indeterminate IGRA results were 39.2%, 56.7%, and 4.2%, respectively. There was no significant differences in subjects characteristics between positive and negative IGRA subjects. The MIS>5 was shown to have no statistically significant association with positive IGRA subjects (OR=3.47, 95%CI 0.93–12.93).Conclusion: Malnutrition based on an MIS score of less than 5 is not statically associated, but clinically associated, with latent TB. Further causal inference study to investigate these associations is needed.

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