Arif Santoso
Hasanuddin University

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Korelasi antara Kadar Kalsium Serum dengan Fungsi Paru pada Penderita Penyakit Paru Obstruksi Kronik (PPOK) Farah Fauziah R.Ahmad; Arif Santoso; Andriany Qanitha
Jurnal Ilmu Kesehatan Masyarakat Vol 9 No 01 (2020): Jurnal Ilmu Kesehatan Masyarakat
Publisher : Sekolah Tinggi Ilmu Kesehatan Indonesia Maju (STIKIM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (544.117 KB) | DOI: 10.33221/jikm.v9i01.488

Abstract

Patologi PPOK menunjukkan gangguan inflamasi kronis yang dapat menyebabkan penyumbatan aliran udara di paru-paru, sedangkan kalsium diketahui memiliki kemampuan mengembalikan aspek respon bawaan. Kalsium juga memiliki peran dalam proses pergerakan otot pernapasan sebagai kompensasi untuk hambatan aliran udara. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar kalsium serum dan fungsi paru pada pasien dengan PPOK. Penelitian ini menggunakan desain cross-sectional dengan analitik observasional, dilakukan selama 2 bulan, dengan total sampel 36 orang pasien PPOK. Berdasarkan hasil analisis data, diketahui bahwa tidak ada hubungan antara kadar kalsium serum dengan fungsi paru pada pasien PPOK (P> 0,05). Diperlukan penelitian lebih lanjut dengan sampel yang lebih besar dan penelitian dengan menggunakan variabel lebih spesifik seperti serum ion kalsium.
Analysis of Vitamin D Levels on Bronchiectasis Severity Yacob Arawamin Batkunde; Muhammad Ilyas; Irawaty Djaharuddin; Nur Ahmad Tabri; Harun Iskandar; Arif Santoso
Respiratory Science Vol. 1 No. 2 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i2.11

Abstract

Background: Bronchiectasis is a chronic disease caused by repeated infection and inflammation of the bronchial walls. Vitamin D plays a role secretion of antimicrobial peptide and inhibits release of pro-inflammatory cytokines in the lungs. Vitamin D deficiency is associated with exacerbations, severity and decreased lung function in bronchiectasis. Several studies have found an association between vitamin D levels and bronchiectasis severity. Methods: This study used cross-sectional study design with consecutive sampling method on bronchiectasis patients who enrolled outpatient and inpatient at Wahidin Sudirohusodo hospital in February - May 2020. All research procedures obtained the approval of the Health Research Ethics Commission, Medicine faculty, Hasanuddin University Makassar. Bronchiectasis severity was assessed based on the FACED score (FEV1, Aged, chronic Colonization by Pseudomonas aeuroginosa, radiological Extension of the disease, Dyspnea). Levels of vitamin D serum {25 (OH) D} were checked using the ELISA method. Results: The study subjects were 44 patients, consisting of 61.4% male and 38.6% female. Most of the bronchiectasis patients in this study were mild (77.3%) based on the FACED score, 15.9% moderate and 6.8% severe. As many as 77.3% of patients had vitamin D deficiency and insufficiency as much as 9.1%. All patients with moderate-severe FACED scores had vitamin D deficiency. The correlation between vitamin D levels and FACED scores showed a positive significant with p-value 0.04. Conclusion: Low vitamin D levels are a risk factor for aggravating bronchiectasis severity and have a positive significant correlation between the two.