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Rahmawida Putri
Sekolah Tinggi Farmasi Muhammadiyah Tangerang, Tangerang
Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : Journal of Pharmaceutical and Health Research

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Formulasi dan Uji Aktivitas Sediaan Masker Gel Peel Off Ekstrak Etanol 70% Daun Rambutan (Nephelium Lappaceum L.) Terhadap Propionibacterium Acnes Rahmawida Putri; Jaka Supriyanta; Dwi Afriliyani Adhil
Journal of Pharmaceutical and Health Research Vol 2 No 1 (2021): Februari 2021
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.719 KB) | DOI: 10.47065/jharma.v2i1.836

Abstract

Rambutan Leaves (Nephelium Lappaceum L.) one of the plants that contain, alkaloids, flavonoids, tannins and saponins have antibacterial activity against Propionibacterium acnes which is a bacterium that causes acne. Rambutan leaf extract can be formulated to facilitate its use, one of which is in the form of a gel such as a peel off mask. This study aims to determine the characteristics of peel off mask preparations and to determine the antibacterial activity of ethanol extract 70% rambutan leaves (Nephelium Lappaceum L.) Peel off gel mask preparations 70% ethanol extract rambutan leaves (Nephelium Lappaceum L.) formulated into 4 formulas with a variety of extract concentrations, namely F1 (0%), F2 (10%), F3 (15%), F4 (20%). Physical evaluation tests which include: organoleptic, homogeneity, pH, viscosity, dry time, spreadability, adhesion, and irritation. And the antibacterial activity test was carried out against Propionibacterium acnes bacteria using the well method. The results showed that the physical evaluation was said to be good to meet the requirements. Antibacterial test results of gel peel off mask preparation of 70% ethanol extract of rambutan leaves (Nephelium Lappaceum L.) showed the existence of antibacterial activity against Propionibacterium acnes bacteria inhibition was the best at the concentration of F4 (20%) with an average diameter of 10.03 mm. One way ANOVA analiysis result showed that there wewre significant differences in each formula group (p<0,05).
Formulasi dan Evaluasi Fisik Sediaan Gel Antiseptik Tangan Dari Ekstrak Etanol 96% Daun Pandan Wangi (Pandanus Amaryllifolius Roxb) Siti Marina; Banu Kuncoro; Sofi Nurmay Stiani; Rahmawida Putri
Journal of Pharmaceutical and Health Research Vol 2 No 1 (2021): Februari 2021
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (322.168 KB) | DOI: 10.47065/jharma.v2i1.837

Abstract

Antiseptic serves to kill or inhibit the growth of bacteria that can cause the onset of disease. Antiseptics can be formulated with natural ingredients so that they are environmentally friendly. Pandan wangi leaf is a plant that is often used as a food additive leaves, as a green dye and aroma. Pandan fragrance is also one of the plants that can be used as antiseptic formulations because it has antibacterial activity and can be used as a topical preparation in the form of gels. The aim of this research is to know the difference of pandan wangi leaf extract concentration (Pandanus amaryllifolius Roxb.) Which has optimum physical properties evaluation. This research is an experimental research, maseration method used to get extract with 96% ethanol. The gel was formulated into four formulas with various extract concentrations of 10%, 20%, 30%, and 40%. Evaluation tests include: organoleptic, homogeneity, pH, dispersion, viscosity, stability, hedonic, irritation and hand antiseptic testing. The results showed that the concentration of extract had no effect on pH and homogeneity. Increased concentration of extract effect on the color change and aroma. The higher concentration of extract will be more concentrated also color. The result of stability inspection showed that texture change in F2 and aroma change in F3. A good gel preparation formula based on physical quality and hedonic test is a concentration formula of 10% (F1). Keywords: Pandanus amaryllifolius Roxb., Hand Antiseptic, Gel.
Co-Authors Banu Kuncoro Dwi Afriliyani Adhil Jaka Supriyanta Siti Marina Stiani, Sofi Nurmay