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All Journal VALENSI Jurnal Kimia (Journal of Chemistry) Jurnal Veteriner JURNAL ILMIAH SAINS Jurnal ILMU DASAR Jurnal Natur Indonesia Majalah Kedokteran Bandung Jurnal Sains dan Terapan Kimia Cropsaver : Journal of Plant Protection Indonesian Journal of Cancer Chemoprevention Journal of Mathematical and Fundamental Sciences Indonesian Journal of Pharmaceutical Science and Technology STOMATOGNATIC- Jurnal Kedokteran Gigi Dentino The Indonesian Biomedical Journal Padjadjaran Journal of Dentistry Kartika Jurnal Ilmiah Farmasi Jurnal Bioteknologi & Biosains Indonesia (JBBI) JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu dan Teknologi Kayu Tropis Jurnal Penelitian Hasil Hutan
Unang Supratman
Universitas Jenderal Achmad Yani
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Veterinary

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7-HIDROKSI-6-METOKSI KUMARIN (SKOPOLETIN) DARI KULIT BATANG Chisocheton celebicus (MELIACEAE) Katja, Dewa G.; Sonda, Andre A.; Huspa, Desi Harneti P.; Mayanti, Tri; Supratman, Unang
Jurnal Kimia (Journal of Chemistry) Vol. 9, No. 2 Juli 2015
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (72.382 KB) | DOI: 10.24843/JCHEM.2015.v09.i02.p18

Abstract

7-hydroxy-6-methoxy coumarin (scopoletin) has been isolated from the bark of Chisocheton celebicus (Meliacee) using several chromatographic techniques.  The chemical structure of 7-hydroxy-6-methoxy coumarin was identified on the basis of spectroscopic data including UV, IR, 1D-NMR, 2D-NMR and mass along with by comparison with those spectral data previously reported. The discovery of scopoletin from the bark C. celebicus reported for the first time in this study.
An Isoflovonoid, Warangalone from the Stem Bark of Dadap Ayam (Erythrina variegata) Herlina, Tati; Nasrudin, Nasrudin; Supratman, Unang; Subarnas, Anas; Sutardjo, Supriyatna; Hayashi, Hideo
Jurnal ILMU DASAR Vol 9 No 1 (2008)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

In the course of our continuing search for novel paralytic compound from Indonesian plants, the methanol extract of the stem bark of Erythrina variegata (Leguminosae) showed significant paralytic activity against the third instar larvae of silkworm (Bombyx mori). The purposes of this research were isolation and structural elucidation of paralytic compound from the stem bark of E. variegata. Using the paralytic activity following the separation, the methanol extract was separated by combination of column chromatography to yield prenylisoflavone, warangalone. The chemical structure of warangalone was identified based on spectroscopic evidence and comparison with the previous reported. The paralytic activity of warangalone showed weak activity against the third instar larvae of silkworm (B. mori).
SINTESIS PEPTIDA P251-9 BERGUGUS PELINDUNG DENGAN METODE SINTESIS PEPTIDA FASA PADAT FMOC/TBU MENGGUNAKAN ADITIF OKSIMA Hardianto, Ari; Subroto, Toto; Supratman, Unang
Jurnal Sains dan Terapan Kimia Vol 5, No 2 (2011)
Publisher : Jurnal Sains dan Terapan Kimia

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Abstract

Peptida P25 merupakan epitop yang dapat dengan mudah mengaktivasisel T penolong. Sel T penolong teraktivasi berperan dalam aktivasi sel Buntuk membentuk antibodi. Peptida bahkan protein dapat dibuat denganmetode sintesis peptida fasa padat Fmoc/tBu menggunakan aditif HOBt.Namun sayangnya HOBt memiliki karakter yang mudah meledak. Padapenelitian ini telah berhasil disintesis bagian epitop P25 (peptida P251-9bergugus pelindung) yang memiliki tingkat kemurnian tinggi dan perolehan36,4% dengan metode sintesis peptida fasa padat Fmoc/tBu menggunakanaditif oksima pengganti HOBt.Kata kunci: Epitop, P251-9, sintesis peptida fasa padat Fmoc/tBu, oksima.
Insecticidal Bufadienolides from The Leaves of Kalanchoe daigremontiana (Crassulaceae) Hermawan, Wawan; Maharani, Rani; Fajriah, Sofa; Hardiawan, Revan; Supratman, Unang
Jurnal ILMU DASAR Vol 11 No 2 (2010)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

Kalanchoe is the biggest genera of Crassulaceae family and distributed in tropical and subtropical regions. This genera is found to be a rich source of biologically active natural products such as triterpenes, flavonoids and steroids. As a part of our continuing search for novel insecticidal compounds from Indonesian Kalanchoe plants, we examined Kalanchoe daigremontiana collected from Bandung region, West Java, Indonesia. The methanolic extract of the dried leaves of K. daigremontiana was concentrated and extracted with methylene chloride The methylene chloride extract exhibited an insecticidal activity toward silkworms. The methylene chloride extract was partitioned between n-hexane and methanol containing 10% water. The active lower layer was extracted with ethyl acetate. By using the insecticidal activity to follow the separations, the ethyl acetate fraction was separated by combination of column chromatography on Kieselgel 60 and ODS to afford two insecticidal bufadienolides 1 and 2. The structures of these compounds were elucidated based on spectroscopic analysis (UV, IR, NMR, 2D-NMR) and comparison with those related data previously reported. In this paper, the isolation, structural elucidation, and insecticidal activities against the third instar larvae of silkworm will be described.
FLAVONOLS FROM THE LEAVES Lygodium microphyllum (Lygodiaceae) Kuncoro, Hadi; Farabi, Kindi; Julaeha, Euis; Rijai, Laode; Shiono, Yoshihito; Supratman, Unang
Jurnal Kimia (Journal of Chemistry) Vol. 11. No. 1 Januari 2017
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.797 KB) | DOI: 10.24843/JCHEM.2017.v11.i01.p02

Abstract

Flavonol compounds, quercetin (1) and quercetin-3-O-?-D-glucopyranoside (2) have been isolated from the ethyl acetate extract of Lygodium microphyllum leaves. The chemical structures of flavonol compounds were identified based on spectroscopic data and by comparison of spectral data obtained previously. The discovery of flavonol compounds in Lygodium microphyllum was shown in this study for the first time.
STIGMASTANE-STEROID FROM THE BARK OF Chisocheton lasiocarfus (Meliaceae) Nurlelasari, Nurlelasari; Abdullah, Fajar Fauzi; Thufaila, Nadya; Maharani, Rani; Harnet, Desi; Hidayat, Ace Tatang; Supratman, Unang
Jurnal Kimia (Journal of Chemistry) Vol. 11. No.2 Juli 2017
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.211 KB) | DOI: 10.24843/JCHEM.2017.v11.i02.p11

Abstract

Stigmastan-steroid, stigma-4-ene-3-on (1) has been isolated from the bark of Chisocheton lansiocarpus. The chemical structure of stigmastan-steroid was identified based on spectroscopic data and by comparison of spectral data obtained previously. The discovery of stigma-4-ene-3-on in C. lansiocarpus was shown in this study for the first time.
In Vitro Anti-Cancer Alkaloid and Flavonoid Extracted from the Erythrina variegata (Leguminoseae) Plant Herlina, Tati; Supratman, Unang; Subarnas, Anas; Sutardjo, Supriyatna; Amien, Suseno; Hayashi, Hideo
Indonesian Journal of Cancer Chemoprevention Vol 2, No 3 (2011)
Publisher : Indonesian Research Gateway

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Abstract

Erythrina plants, locally known as “dadap ayam”, are higher plant species and have been used as a folk medicine for treatment of cancer. To prove the effectiveness of the leaves and stem bark of E. variegata as an anti-cancer agent, the assay in this research was focused on in vitro  test  towards  breast  cancer  cell  T47D.  In  the course  of  our  continuing  search  for novel anti-cancer agent from Erythrina plants, the methanol extract of the leaves and stem bark of  E. variegata  showed  significant  anti-cancer  activity  against  breast  cancer  cell  T47D  in  vitro  using the Sulphorhodamine B (SRB) assay. By using the anti-cancer activity to follow the separations, the methanol extract was separated by combination of column chromatography. The chemical structure  of  an  anti-cancer  compounds  were  determined  on  the  basis  of  spectroscopic evidence  and  comparison  with  the  previously  reported  and  identified  as  an  erythrina  alkaloid (1)  and  isoflavonoid  (2).  Compounds  (1-2)  showed  anti-cancer  activity  against  breast  cancer cell  T47D  used  with  IC50  of    1.0  and  3.3  µg/mL,  respectively.  This  results  strongly  suggested that E. variegata is promising sources for anti-cancer agents.Keywords: Anti-cancer, Erythrina variegata, Leguminoseae
Aktivitas Antimalaria Daun Erythrina variegata Herlina, Tati; Supratman, Unang; Subarnas, Anas; Sutardjo, Supriyatna; Abdullah, Noor Rain
Jurnal Natur Indonesia Vol 10, No 1 (2007)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jnat.10.1.36-41

Abstract

The leaves of Erythrina variegata (Leguminosae) used tradisional plant of an antimalarial. In the course of our continuing search for novel an antimalarial compound from Erythrina plants, the methanol extract of the leaves ofE. variegata showed significant antimalarial activity in vitro toward Plasmodium falciparum in vitro using the lactate dehydrogenase (LDH) method. The methanol extract of the leaves of E. variegata showed against bothstrains of parasite with IC50of 6.8 ?g/ml against K1 and > 60 ?g/ml against 3D7, respectively. The methanol extract of the leaves of E. variegata was separated by using bioassay-guide fractionation. The n-buthanol fraction yieldedthe most activity, exhibiting equipotency against both strains of parasite with IC50of 5.1 ?g/ml against K1 and 13.5 ?g/ml against 3D7, respectively. Furthermore, by using the antimalarial activity to follow separation, the n-buthanol fraction was separated by combination of column chromatography to yield an active compound. The active compound showed antimalarial activity against both strains of parasite used with IC50 of 4.3 ?g/ml against K1 and 23.5 ?g/ml against 3D7, respectively. Its inhibition of the resistant strain (K1) was also much better compared to its inhibition of the sensitive strain (3D7), indicated that the leaves of E. variegata to be potential as antimalarial agents, but its lower potency compared to artemisinin and chloroquin.
Kuersetin dari Daun Erythrina poeppigiana (leguminosae) Herlina, Tati; Supratman, Unang
Jurnal Natur Indonesia Vol 17, No 1 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (76.854 KB) | DOI: 10.31258/jnat.17.1.1-4

Abstract

Erythrina plants known plants “dadap” is a higher plant that grows in tropical and subtropical regions. E. poeppigiana plants was a source of secondary metabolites, which contain flavonoids. This study aims to isolate the flavonoid compounds from the leaves of  E. poeppigiana through the stages of extraction, fraction, separation and purification. E. poeppigiana leaves powder (2.5 kg) was extracted with methanol and partitioned with n-hexane and ethyl acetate. Furthermore, the separation of ethyl acetate of E. poeppigiana leaves fraction using a combination of column chromatographic was obtained pure compound (5 mg) in the form of a yellow amorphous  solid. The chemical structure of pure compound was based on the data spectroscopy (MS, UV, IR, 1H-NMR and 13C-NMR) and identified as the compound 3,3 ‘, 4’, 5,7-pentahidroksiflavon or known as quercetin.
Kuersetin dan Kuersetin-3-O-Glukosida dari Kulit Batang Sonneratia Alba (Lythraceae) Horizon, .; Pujiastuti, Betry; Kurnia, Dikdik; Sumiarsa, Dadan; Supratman, Unang; Shiono, Yoshihito
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 1, No. 1, Mei 2015
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (463.988 KB) | DOI: 10.15408/jkv.v0i0.3151

Abstract

Two flavonoid compounds, quercetin (1) and quercetin-3-O-glucoside (2) have been isolated from the bark of Sonneratia alba (Lythraceae). Chemical structure of both compounds were determined on the basis of spectroscopic data and comparison with those spectra data previously reported. Compound 1 and 2 exhibited antibacterial activity against Gram-positive bacteria, Staphylococcus aureus and Streptococcus mutans with MIC values of 51.2; 48.8; 72.5; dan 100.7 µg/mL respectively.DOI :http://dx.doi.org/10.15408/jkv.v0i0.3151
Co-Authors . Susianti Abd Ghani, Muhammad Solehin Ace Tatang Hidayat Achmad Zainuddin Ade Kania Ningsih, Ade Kania Adel Zamri Agus Safari Ali, Mohamed Ashraf Amir, Nur Insani Anas Subarnas Anas Urbanas Andre A. Sonda, Andre A. Anwar, Risyandi Ari Hardianto Ari Widiyantoro Arif Rahman Hakim Arlette Setiawan, Arlette Arlette Suzy Setiawan, Arlette Suzy Arto Yuwono Soeroto, Arto Yuwono Asep Supriadin, Asep Awang, Khlaijah Azmi, Mohamad Nurul Dadan Sumiarsa Danar Dono Darmawan, Ahmad Darwati Darwati Desi Harneti Destiarti, Lia Dewa G Katja Dewa G. Katja Dewa Gede Katja Dikdik Kurnia Edi Suanto, Edi Edi Sukmana Efza, Ferdyan Elvi Rusmiyanto, Elvi Euis Julaeha Faizal Hermanto, Faizal Fajar Fauzi Abdullah Fajar, Mohamad Fajar, Mohamad Farabi, Kindi Farabi, Kindi Fitriana, Ronauli Goenawan, Hana Goenawan, Hanna Gunadi, Julia Windi Hadi Kuncoro Haikal, Kansy Harlia, Harlia Harnet, Desi Hasnah Osman Hassan, Mohd. Zaheen Hendra, Rudi Hideo Hayashi Hilmayanti, Erina Horizon, . Husein Hernandi Bahti Indriyani, Indri Inne Suherna Sasmita Iqbal, Gilang Muhamad Nur Iwan Setiawan Izdihar, Ghina Juliati, Nova Sylviana Kamarulzaman, Ezatul Ezleen Khairani, Astrid Feinisa Krismayanti, Elisabeth Kurniawan, Ahmad Laode Rijai Lesmana, Ronny Lilis Siti Aisyah, Lilis Siti Lindung Tri Puspasari Mahendra, Isa Mantiri, Sisilia A Mardianingrum, Richa Mariati, Dimpuulina Erna Maryati Maryati Max R.J Runtuwene Milawati, Hersa Milawati, Hersa Mohamad Taib, Mohamad Nurul Azmi Mohamed Yusoff, Nadia Naini, Al Arofatus Nasrudin Nasrudin Noor Rain Abdullah Nova Sylviana, Nova Nunung Kurniasih, Nunung Nurfarida, Ida Nurlelasari Nurlelasari Nurlelasari, Nur Paramita, Hedi Prasetyo, Wibowo Budi Prayudi Santoso Pujiastuti, Betry Rahmayanti, Intan Rahmi, Jihan Mudrika Rani Maharani Ratu Safitri Ray, Hamidie Ronald Daniel Revan Hardiawan RIKA MELIANSYAH Rizky Abdulah, Rizky Roosje Rosita Oewen, Roosje Rosita Roro Wahyudianingsih, Roro Rosdianto, Aziiz Mardanarian Rymond J. Rumampuk S. Supriatno, S. Salam, Supriatno Sari, Aprilia Permata Setiawan Setiawan Shiono, Yoshihito Shiono, Yoshihito Soedjanaatmadja, M. S. Sofa Fajriah Sukmawati, Winda Sunarjati Sudigdoadi Supriatno Supriatno Supriyatna Supriyatna Supriyatna Sutardjo Suseno Amien Susianti, Susianti Syamsunarno, Mas Rizky Anggun Adipurna Taib, Mohamad Nurul Azmi bin Mohamad Tati Herlina Taylor, W.C. Thufaila, Nadya Toto Subroto Tri Mayanti Tri Reksa Saputra, Tri Reksa Tsamrotul, Alya Vita Murniati Tarawan Wahyuni, Aneu Wawan Hermawan Wismandanu, Okta Yenita, Fani Rahma Yenny Febriani Yun, Yenny Febriani Yoon, Yeong Keng Yum Eryanti Yuni Susanti Pratiwi, Yuni Susanti Yusup Hidayat