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R. Susworo
Department of Radiotherapy,Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital,Jakarta
Medicine & Pharmacology

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Post-irradiation osteosarcoma : A case report Hutagalung, Errol U.; Basuki, Achmad; Susworo, R.
Medical Journal of Indonesia Vol 9, No 4 (2000): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (353.487 KB) | DOI: 10.13181/mji.v9i4.627

Abstract

[no abstract available]
Genotype distribution of T cell receptor β gene in Indonesian nasopharyngeal carcinoma patients Yurnadi, Yurnadi; Soeharso, Purnomo; Suryandari, Dwi A.; Moeloek, Nukman; Susworo, R.
Medical Journal of Indonesia Vol 20, No 3 (2011): August
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (481.273 KB) | DOI: 10.13181/mji.v20i3.446

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Background: Nasopharyngeal carcinoma (NPC) is a multifactorial genetic disease, characteristically endemic and shows considerable differences in its geographical distribution. Besides infection with EBV, genetic factors such as polymorphisms of TCR-β gene contribute to the incidence of NPC. This study investigates the association of TCR-β gene polymorphisms with individual susceptibility to develop NPC in Indonesian ethnic groups.Methods: The study was carried out by the PCR-RFLP method using Bgl II restriction enzyme to digest TCR-β gene. The PCR-RFLP analysis of TCR-β gene was used to determine allotypes of TCR-β gene in NPC patients and control among ethnic Chinese and indigenous groups in the population of Indonesia.Results: The results indicate that the distribution of TCR-β gene allotypes between NPC patients and controls are not significantly different (p > 0.05); however, the frequency of A allele tends to increase in NPC patients. The distribution of TCR-β gene allotypes between Chinese ethnic group was not signifi cantly different from indigenous groups (p > 0.05).Conclusion: The distribution of TCR-β gene allele between NPC group and control groups showed no difference. The distribution of TCR-β gene between ethnic Chinese and indigenous groups showed no difference. Polymorphisms of TCR-β gene are not associated with NPC and ethnic groups in Indonesian population. (Med J Indones 2011; 20:171-7)Keywords: EBV, NPC, polymorphism, susceptibility, TCR-ß gene
Flow-cytometric DNA content and S-phase fraction values as a prognostic factor on nasopharyngeal cancer - a preliminary report Gondhowiardjo, S.; Susworo, R.; Kresno, S. B.; Hartini, S.; Roezin, A.; Kurniawan, A. N.
Medical Journal of Indonesia Vol 6, No 1 (1997): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (859.941 KB) | DOI: 10.13181/mji.v6i1.806

Abstract

[no abstract available]
Biocompatibility of various hydoxyapatite scaffolds evaluated by proliferation of rat’s bone marrow mesenchymal stem cells: an in vitro study Kamal, Achmad F.; Iskandriati, Diah; Dilogo, Ismail H.; Siregar, Nurjati C.; Hutagalung, Errol U.; Susworo, R.; Yusuf, Achmad A.; Bachtiar, Adang
Medical Journal of Indonesia Vol 22, No 4 (2013): November
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (516.004 KB) | DOI: 10.13181/mji.v22i4.600

Abstract

Background: Scaffold (biomaterial) biocompatibility test should be performed in vitro prior to in vivo stem cell application in animal or clinical trial. These test consists of direct and indirect toxicity test (MTT assay [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]). Those tests were used to identify cell morphological changes, cell-substrate adhesion impairment, and reduction in cell proliferation activity.Methods: The tested scaffolds were hydroxyapatite-calcium sulphate (HA-CaSO4) (scaffold I), nano-particular HA paste (scaffold II), synthetic HA granule (scaffold III), bovine HA granule (scaffold IV), and morsellized bovine xenograft (scaffold V). Direct contact toxicity test and MTT assay [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] were performed on those groups. In direct contact toxicity test, we put granules of various scaffolds within plates and incubated together with mesenchymal stem cells (MSCs). In MTT assay we included phenol 20 mg/mL and 100 mg/mL group as positive control. Morphology, cell adhesion impairment, and cell growth were monitored daily until day-7. Cells counting in the direct contact toxicity test was conducted on day-7.Results: There were no changes on 24 hours observation after direct contact. On day-7, an impairment of cell adhesion to plastic substrates, changes in cell morphology, and cell death were observed, especially in scaffold I, scaffold II, and scaffold V. In MTT assay, only scaffold I, phenol 20 mg/mL, and phenol 100 mg/mL showed more than 50% inhibition at 24-hour and 7-day-observation. Extracts from scaffold II, III, IV, and V did not affect the viability and proliferation of bone marrow MSCs (inhibition value < 50%). Scaffold II, III, IV and V were proven non-cytotoxic and have good biocompatibility in vitro,  no statistical significant differences were observed among the scaffold groups (p > 0.05).Conclusion: We understand which scaffold was nontoxic or the least toxic to MSCs in vitro. Scaffold IV (bovine HA granule) showed the least toxic effect to rat’s bone marrow MSCs on direct contact test and MTT assay. (Med J Indones. 2013;22:202-8. doi: 10.13181/mji.v22i4.600)Keywords: Biocompatibility test, direct contact test, hydroxyapatite, MTT assay, scaffold
Fluconazole administration during irradiation of head and neck cancer Susworo, R.; Sjarifuddin, Pudji K.; Gondhowiardjo, Suhartati; Juniarti, Juniarti
Medical Journal of Indonesia Vol 1, No 3/4 (1992): July-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1552.513 KB) | DOI: 10.13181/mji.v1i3/4.3618

Abstract

[no abstract available]
Nasopharyngeal carcinoma: an alternative histological classification as a working formulation Kurniawan, A. N.; Syafril, Anida; Susworo, R.
Medical Journal of Indonesia Vol 2, No 1 (1993): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1592.771 KB) | DOI: 10.13181/mji.v2i1.3595

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[no abstract available]
Co-Authors A. N. Kurniawan A. Roezin A.A. Ketut Agung Cahyawan W Achmad A. Yusuf Achmad Basuki Achmad F. Kamal Adang Bachtiar DIAH ISKANDRIATI Dwi A. Suryandari Errol U. Hutagalung Gondhowiardjo, Suhartati Ismail H. Dilogo Nukman Moeloek Nurjati C. Siregar Purnomo Soeharso S. B. Kresno S. Gondhowiardjo Sjarifuddin, Pudji K. Sri Hartini Syafril, Anida Yurnadi Yurnadi