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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Sains dan Kesehatan Jurnal Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian
Annisa Farida Muti
Universitas Pembangunan Nasional Veteran Jakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Medical Sains : Jurnal Ilmiah Kefarmasian

 1 
IN VITRO ACUTE TOXICITY OF DANDELION LEAF EXTRACT (Taraxacum officinale F.H.Wigg) WITH BRINE SHRIMP LETHALITY TEST (BSLT) METHOD Dian Mega Sugiyarto; Annisa Farida Muti; Dhigna Luthfiyani Citra Pradana; Eldiza Puji Rahmi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.873

Abstract

Toxicity is a characteristic feature of substances that can cause harmful effects. This study aimed to determine the toxicity of dandelion leaves (Taraxacum officinale F.H. Wigg) to Artemia salina Leach larvae within 24 hours. Dandelion leaves were extracted using a maceration method with 50% ethanol. The yield was 5.88%. The results showed that dandelion leaves contain alkaloids, flavonoids, steroids, triterpenoids, and phenols. Toxicity tests were performed using the Brine Shrimp Lethality Test method, where the final result was the LC50 value. Artemia salina Leach larvae were divided into five groups. Each group had ten larvae that underwent three replications. The 50%ethanolic extract of dandelion leaf concentrations in the treatment media were 50 ppm (P1), 100 ppm (P2), 150 ppm (P3), 200 ppm (P4), and 0 ppm (seawater) as the control. Probit analysis of Artemia Salina Leach mortality percentage data. The results indicated that the 50%ethanolic extract of dandelion leaves is harmful to larvae, with LC50 values of 165,223 ppm (toxic) or in the equation y = 2,114x + 0,311, with an R² value of 0,9435. Keywords: Artemia salina, BSLT, Dandelion leaf, LC50, Toxicity
Co-Authors Alya Andina Dasuki Asri Yani Chanica Anindya Dhigna Luthfiyani Citra Pradana Dian Mega Sugiyarto Eldiza Puji Rahmi Eldiza Puji Rahmi Emma Rahmawati Hany Yusmaini Moh. Benny Perdana Nurul Octavia Rahmawati, Emma Refdanita Refdanita Sister Sianturi Sukardiman Veronica Anggelita Putri