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All Journal Narra J
Deepak Chandran
Department of Veterinary Sciences and Animal Husbandry, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, India
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Acute severe hepatitis of unknown etiology in children: A mini-review Andri Frediansyah; Malik Sallam; Amanda Yufika; Khan Sharun; Muhammad Iqhrammullah; Deepak Chandran; Sukamto S. Mamada; Dina E. Sallam; Yousef Khader; Yohannes K. Lemu; Fauzi Yusuf; James-Paul Kretchy; Ziad Abdeen; J. Smith Torres-Roman; Yogesh Acharya; Anastasia Bondarenko; Aamer Ikram; Kurnia F. Jamil; Katarzyna Kotfis; Ai Koyanagi; Lee Smith; Dewi Megawati; Marius Rademaker; Talha B. Emran; Ziad A. Memish; Sandro Vento; Firzan Nainu; Harapan Harapan
Narra J Vol. 2 No. 2 (2022): August 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i2.83

Abstract

The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA–E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.
Monkeypox virus infection and myocarditis: A review of current evidence and possible pathogenesis Sirwan K. Ahmed; Eman A. Dabou; Shaimaa Abdelsamad; Mona G. Mohamed; Deepak Chandran; Sandip Chakraborty; Talha B. Emran; Kuldeep Dhama
Narra J Vol. 3 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i1.104

Abstract

The recent spread of the monkeypox virus (MPXV), causing monkeypox (mpox), to non-endemic areas, and the atypical and unusual clinical manifestations observed during its 2022 outbreak has focused international interest on the clinical features of the disease. Mpox is usually a self-limiting disease with mild symptoms with common manifestations, including fever and skin lesions; however, severe manifestations could occur in some vulnerable groups (children and those with impaired immune systems) and may present multisystem complications and fatal outcomes. In most cases, a fever is the first sign of disease, followed by the development of various inflammatory lesions on the skin, such as vesiculopustular rashes and ulcers. Pneumonitis, encephalitis, keratitis, secondary bacterial infections, acute kidney injury, and myocarditis are all possible outcomes of the infection. Myocarditis has been reported to be caused by orthopoxviruses, and it is a serious condition of which its pathophysiology is little understood. Recent reports have indicated myocarditis with cardiac involvement as a possible atypical and unusual consequence of the MPXV infection during present outbreak. This review provides an overview of the clinical manifestations of mpox with a special focus on its effects on the heart, including myocarditis. The evidence of the myocarditis in mpox patients and its possible pathogenesis are discussed.
Co-Authors Aamer Ikram Ai Koyanagi Amanda Yufika Anastasia Bondarenko Andri Frediansyah Dewi Megawati Dina E. Sallam Eman A. Dabou Fauzi Yusuf Firzan Nainu Harapan Harapan J. Smith Torres-Roman James-Paul Kretchy Katarzyna Kotfis Khan Sharun Kuldeep Dhama Kurnia F. Jamil Lee Smith Malik Sallam Marius Rademaker Mona G. Mohamed Muhammad Iqhrammullah Sandip Chakraborty Sandro Vento Shaimaa Abdelsamad Sirwan K. Ahmed Sukamto S. Mamada Talha B. Emran Talha B. Emran Yogesh Acharya Yohannes K. Lemu Yousef Khader Ziad A. Memish Ziad Abdeen