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All Journal Jurnal Ilmiah Farmasi Akademi Farmasi Jember
Dewi Rashati, Siti Mursidatur Rohmah
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Medicine & Pharmacology

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Journal : Jurnal Ilmiah Farmasi Akademi Farmasi Jember

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UJI FISIK FORMULASI TABLET FLOATING TEOFILIN DENGAN MATRIK HPMC Dewi Rashati, Siti Mursidatur Rohmah
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2016: April - Vol.1 No.1
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.082 KB) | DOI: 10.53864/jifakfar.v1i1.6

Abstract

The purpose of this study was to determine the physical properties of theophylline floating tablet formulation with HPMC as matrix. Floating tablets of theophylline is manufactured by direct compression. Composition per tablet formulation consisting of theophylline 270 mg, HPMC, avicel, magnesium stearate, and sodium bicarbonate. The results of data showed average of tablet weight uniformity 501mg, tablet hardness 6,99 kg, tablet friability 0,593%, disintegration time of tablets 738 seconds, floating lag time (FLT) 584,3 seconds and floating duration time (FDT) more than 8 hours. Floating tablet formulation of theophylline resulted in a good physical test.Keyword: floating, theophylline, HPMC, tablet
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