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All Journal Jurnal Kedokteran Syiah Kuala Folia Medica Indonesiana The Indonesian Biomedical Journal Indian Journal of Forensic Medicine & Toxicology Ophthalmologica Indonesiana Vision Science and Eye Health Journal Ophthalmologica Indonesiana
Komaratih, Evelyn
Department Of Ophthalmology, Faculty Of Medicine, Universitas Airlangga/Dr.Soetomo General Hospital, Jl. Mayjen. Prof. Dr. Moestopo No. 47, Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Physics Public Health Other

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Journal : Ophthalmologica Indonesiana

 1 
Anti-Inflammation and Anti-Fibrotic Effects of Amniotic Membrane on Post-Trabeculectomy Conjunctiva (Experimental Research on Oryctolagus cuniculus) Listya Dyah Rihardini; Suparman Suparman; Evelyn Komaratih
Majalah Oftalmologi Indonesia Vol 42 No 2 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i2.89

Abstract

Background: To evaluate the effects of amniotic membrane transplantation on the modulation ofwound healing after trabeculectomy.Methods: Eighteen eyes of nine New Zealand rabbits: nine left eyes underwent glaucoma filteringsurgery, nine right eyes underwent trabeculectomy and amniotic membrane transplantation. Freshfrozen human amniotic membranes were transplanted above scleral flap, below the conjunctiva withthe stromal side-up. Daily examination of anterior segment were performed using hand held slit lamp.After 7 days, all eyes were enucleated and sent for histopathology examination to evaluate theinflammatory and fibroblast cells. The rabbits were terminated. Blebs were well formed until 7 days.Results: There were statistically no significant difference between two groups in quantity ofinflammatory cells (p=0.258) and fibroblast cells (p=0.436). The tendency in the treatment group,however, the Masson’s Trichrome obtained less fibrosis (88.9%) compared to the control group(44.4%). Hematoxilin eosin staining revealed inflammatory reaction tends to be more severe than thecontrol group, suggesting a xenograft rejection.Conclusion: AMT is still potential as an alternative option to reduce fibrosis in glaucoma filteringblebs but need further research. In rabbits, human amniotic membrane elicited a xenograft reaction.Keywords: amniotic membrane, trabeculectomy, inflammation, fibrosis
CONQUERING THE AMBIGUITY OF OPTIC ATROPHY IN NORMAL TENSION GLAUCOMA: FROM MYSTERY TO MASTERY: Poster Presentation - Case Report - Resident Affannul Hakim; Evelyn Komaratih; Nurwasis; Yulia Primitasari
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/nha7y421

Abstract

Introduction : The dilemma in diagnosing glaucoma often arises when optic atrophy is found alongside nonspecific glaucomatous findings and normal intraocular pressure (IOP), particularly in cases of normal tension glaucoma (NTG). This gray zone often leads to doubt and misdiagnosis. Case Illustration : A 70-year-old man previously diagnosed with idiopathic bilateral optic atrophy complained of blurred vision in both eyes. The visual acuity was 5/5 in the right eye (RE) and hand movement in the left eye (LE). Both eyes had normal IOP, open angles with Sampaolesi lines on gonioscopy, fibrin deposits at pupillary margins, and a large cup-to-disc ratio with baring and peripapillary atrophy on funduscopy. The OCT examination revealed thinning in the ONH-RNFL, ILM-RPE, and GCL-IPL complexes. HFA revealed tunnel vision in RE and general depression in LE. The patient was suspected of having NTG. We performed BMO-MRW (less than 100 ?m in both eyes) and 24-hour ocular perfusion pressure (OPP) measurements (less than 50 mmHg at night) to support the diagnosis. Discussion : The BMO-MRW examination is a new parameter that can help establish the diagnosis of glaucoma. A thin BMO-MRW finding suggests that optic atrophy originates from glaucoma. It is important to perform a comprehensive examination in cases of NTG to identify risk factors and prevent the development of glaucoma. Decreased OPP to less than 50 mmHg and PEX syndrome may be risk factors for NTG. Conclusion : In cases of doubtful optical atrophy, it is important to consider the possibility of NTG by performing a comprehensive examination, including BMO-MRW and twenty-four hour OPP measurements.
ANGLE RECESSION, THE SEQUELA OF EIGHT-BALL HYPHEMA AFTER SPRAYED BY FIRE HYDRANT: A CASE REPORT: Poster Presentation - Case Report - Resident Annisa Kinanti Asti; Evelyn Komaratih; Nurwasis; Yulia Primitasari
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/gkke0y72

Abstract

Introduction : Hyphema results from damage to the blood vessels of the iris or anterior ciliary body after blunt trauma, and in 56–100% of cases can occur angle recession. Case Illustration : A 40-year-old man complaints of pain and blurred left eye after being sprayed by a high-pressure fire hydrant five hours before coming to the emergency room. Visual acuity was 20/20 and hand movement in right and left eye, IOP is 13 mmHg and 18 mmHg in both eyes. Subconjunctival bleeding, conjunctival and pericorneal injections were found with punctate fluorescein test in the left eye. The cornea was edema and the anterior chamber was full of hyphema. Five days after being hospitalized and treated with topical atropine, antibiotics, and steroid in combination with oral tranexamic acid, the visual acuity was 5/6.5 and the hyphema was resolved. The IOP elevated after 1-6 weeks of follow-up in the outpatient clinic then timolol eyedrops were given. Gonioscopy showed widening of CBB, torn iris processus 2 clock hours in the inferior quadrant. The antiglaucoma medication was stopped due to the controlled IOP in the end episode of the treatment. Discussion : Angle recession involves a tear between the longitudinal and circular muscle fibres of the ciliary body. Medication is needed to control the IOP, while surgical management only indicated in cases where medical treatment fails to control the IOP and risk of progressive visual loss. Conclusion : Angle recession can occur after blunt eye trauma with hyphema and IOP control is needed to prevent the development of secondary glaucoma.
GLAUCOMA SECONDARY TO NONSPECIFIC ORBITAL INFLAMMATION: A DIAGNOSIS NOT TO OVERLOOK: Poster Presentation - Case Report - Resident Camilla Amanda Prakoeswa; Evelyn Komaratih; Susy Fatmariyanti
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/ft2tnq30

Abstract

Introduction : Nonspecific Orbital Inflammation (NSOI) is an inflammatory condition of unknown etiology manifesting as pain, ocular motility disturbances, eyelid edema, chemosis, and increased intraocular pressure (IOP). We illustrate a case of glaucoma secondary to NSOI and the importance of understanding the cause-effect relationship between the two conditions. Case Illustration : An eighteen-year-old girl presented with severe pain, ptosis, chemosis, ophthalmoplegia, and increased IOP (38 mmHg) despite a leaking trabeculectomy bleb, on the left eye. She was referredwith the diagnosis of primary angle-closure glaucoma (PACG) and a history of twice trabeculectomy surgeries done elsewhere two months before she came to our hospital. She could not move her lefteye nasally five months before the first surgery and felt joint pains for a year. After thorough diagnostics, she was assessed with left eye NSOI and secondary glaucoma with spondyloarthropathy. Oral prednisone 30 mg/day was given to manage the inflammation and the resultant glaucoma. One week follow-up showed an improved condition with decreased IOP (16 mmHg) despite the same anti-glaucoma therapy regimen. Discussion : NSOI can mimic various diseases, making diagnosis challenging. The raised IOP in NSOI is often caused by extraocular muscles and orbital tissue swelling, which compresses the superior and inferior ophthalmic veins, resulting in choroidal circulation problems. The IOP was quickly reduced once the inflammation was managed. This is a case of secondary glaucoma caused by an overlooked NSOI, aggravated by the immunological process in the orbit after trabeculectomy surgeries. Conclusion : Secondary glaucoma should be considered as a differential diagnosis of PACG in patients with NSOI.
Co-Authors Affannul Hakim Annisa Kinanti Asti Camilla Amanda Prakoeswa Cita Rosita Sigit Prakoeswa Diana Yuliawati Ferdian Ramadhan Herdina Ramadhani Heriyawati Heriyawati Ismi Zuhria Jamaluddin Jamaluddin Listya Dyah Rihardini Luki Indriaswati Ni Made Inten Lestari Ni Putu Ayu Reza Dhiyantari Nurwasis Nurwasis Primitasari, Yulia Suparman Suparman Susy Fatmariyanti Yulia Primitasari Yuyun Rindiastuti Yuyun Rindiastuti Yuyun Rindiastuti