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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences
Ken Ichi Fujita, Ken Ichi
Material Sciences, Faculty of Science, Osaka City University - Japan
Agriculture, Biological Sciences & Forestry Environmental Science

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Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L. Artanti, Nina; Hanafi, Muhammad; Andriyani, Rina; Saraswaty, Vienna; Udin, Linar Zalinar; Lotulung, Puspa D; Fujita, Ken Ichi; Usuki, Yoshinosuke
Journal of Tropical Life Science Vol 5, No 2 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.05.02.06

Abstract

Hedyotis corymbosa, with local name rumput mutiara, is an anti-inflammatory, anti-cancer and hepatoprotective traditional medicine.  The ethanol extract of H. corymbosa L. shows inhibitory activity to human YMB-1 breast cancer cell line with an IC50 of 6.51 mg/ml.  The methylene chloride fraction shows a potential cytotoxic activity with an IC50 of 2.75 mg/ml.  To obtain a lead compound, the extract was further purified by column chromatography. A pure compound is obtained which shows inhibitory activities against YMB-1, HL60 and KB human cell lines with IC50 values of 0.7; 11.0 and 104.2 mg/ml, respectively.  Based on the 1D and 2D FT-NMR data, the isolated compound is an asperuloside.
Co-Authors A.A. Ketut Agung Cahyawan W Linar Zalinar Udin, Linar Zalinar Nina Artanti Puspa D Lotulung, Puspa D Rina Andriyani Vienna Saraswaty, Vienna Yoshinosuke Usuki, Yoshinosuke