This study aims to see the relationship between attitude, distance to health services, and parental support with the willingness to the HPV vaccine in adolescents. This research method is cross-sectional. The results of this study show that attitude (p=0.000) [PR= 2.234, 95% CI 1.512-3.300] and parental support (p=0.028) [PR=1.549, 95% CI 1.041-2.306] have a significant relationship with willingness to vaccinate HPV. Meanwhile, the distance from home to health services (p=0.151) [PR=0.729, 95% CI 0.464-1.145] had no relationship with willingness to vaccinate against HPV. In conclusion, adolescents with good parental attitudes and support are more likely to be willing to vaccinate against HPV. Keywords: Human Papilloma Virus (HPV), Cervical Cancer, Adolescents, Attitudes, Vaccines