Claim Missing Document
Check
Articles

Found 3 Documents
Search
Journal : Indonesian Journal of Cancer

Hubungan Overekspresi HER-2/neu dengan Status Reseptor Hormonal dan Grading Histopatologi pada Penderita Karsinoma Payudara di RS Onkologi Surabaya JACOBUS OCTOVIANUS; SINDRAWATI -; ARIO DJATMIKO
Indonesian Journal of Cancer Vol 6, No 3 (2012): Jul - Sep 2012
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v6i3.204

Abstract

Pendahuluan: Overekspresi HER-2/neu merupakan salah satu faktor prognostik dan faktor prediktif yang penting pada karsinoma payudara. Tujuan: menilai hubungan antara overekspresi HER-2/neu dengan faktor yang berkaitan dengan prognosis dan faktor prediksi, yaitu status Reseptor Hormonal dan Grading Histopatologi pada pasien yang datang ke Rumah Sakit Onkologi Surabaya (RSOS). Metode: penelitian retrospektif dengan mencatat data rekam medis penderita karsinoma payudara baru di RS Onkologi Surabaya, sejak Januari 2007 sampai Desember 2010. Data yang dicatat adalah ekspresi HER-2/neu, grading histopatologi, dan status reseptor hormonal.Hasil: di antara 1.426 penderita baru yang datang di RSOS sejak Januari 2007 sampai Desember 2010, terdapat 844 kasus yang dilakukan pemeriksaan histopatologi dan imunohistokimia untuk status reseptor hormonal ER/PR, dan ekspresi HER-2/neu. Overekspresi dari HER-2/neu didapatkan pada 216 penderita (25,6%). Didapatkan prosentase tertinggi kejadian overekspresi HER-2/neu pada rentang usia 55-59 tahun (36,4%), prosentase tertinggi pada status ER (37,1%), PR- (33,7%), dan grading histopatologi yang tinggi (34,6%). Dari hasil analisis statistik didapatkan hubungan yang signifikan antara overekspresi HER-2/neu dengan status ER/PR dan grading histopatologi (p<0,01).Kesimpulan: didapatkan hubungan yang signifikan antara overekspresi HER-2/neu dengan faktor biologi tumor yaitu status ER/PR, grading histopatologi.Kata Kunci: karsinoma payudara, HER-2/neu, usia, reseptor hormonal, grading histopatologi.
Pregnancy Associated Breast Cancer di Rumah Sakit Onkologi Surabaya 2006 2014 JACOBUS OCTOVIANUS; SAVITRI KUNTARI; ARIO DJATMIKO
Indonesian Journal of Cancer Vol 9, No 2 (2015): April-Juni 2015
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (622.646 KB) | DOI: 10.33371/ijoc.v9i2.377

Abstract

ABSTRACTPregnancy associated breast cancer (PABC) is the most common malignancy in gestation. Due to its high aggressiveness, PABC needs a specific management right from diagnosis process to therapy. The objective of this study is to find out the PABC profile in Rumah Sakit Onkologi Surabaya from 2006-2014. A descriptive study using PABC Medical Record datafrom 2006 until 2014. There were 21 PABC patients of whom 11 was diagnosed on 31-40 years old (52.38%); 16 PABC patients with multiparity (76.19%); 14 (66.67%) PABC diagnosed at 1 year post partum; 18 USG and 6 Mammography examinations, both revealed 100% sensitivity in diagnosing PABC; 14 patients (66,67%) in stadium III-IV; 9 patients (42,86%) with T4 tumor size; 9 patients (42,86%) with axillary lymphnode metastasis ; 4 patients (19,05%) with distant metastasis; 10 patients (47,62%) with Invasive Ductal Carcinoma (IDC); 14 patients (66,67%) grade III; and 8 patients (38,10%) with angioinvasion. Positive ER/PR in 11 patients (52,38%) and positive Her-2 in 10 patients (47,62%). PABC prognosis were: 8 patients (38,10%) in good condition, while 5 patients (23.81%) had distant metastasis, and 4 patients (19,05%) passed away. Twenty one babies born healthy (100%). The aggressiveness of PABC can be seen from the percentage of patients in advanced stage and has worse prognosis.Keywords: breast cancer, pregnancyABSTRAKPregnancy Associated Breast Cancer (PABC) merupakan keganasan yang paling sering ditemukan pada kehamilan. Karena agresivitas yang tinggi, PABC memerlukan penanganan yang khusus, baik saat penegakan diagnosis maupun tindakan terapi. Penelitian ini bertujuan mengetahui profil PABC di Rumah Sakit Onkologi Surabaya sejak 2006-2014. Studi deskriptif ini menggunakan data rekam medis pasien PABC sejak 2006 hingga 2014. Hasil penelitian menunjukkan kasus PABC sebanyak 21 pasien. Jumlah PABC tertinggi ditemukan pada usia 31-40 tahun, yaitu 11 pasien (52,38%); 16 pasien (76,19%) PABC didapatkan pada multiparitas; 14 pasien (66,67%) pada 1 tahun post-partum. Pada 18 pemeriksaan USG dan 6 pemeriksaan mammografi memiliki tingkat sensitivitas 100%; 14 pasien (66,67%) pada stadium III-IV; 9 pasien (42,86%) tumor T4; 12 pasien (57,14%) metastasis ke kelenjar getah bening; 4 pasien (19,05%) metastasis jauh; 10 pasien (47,62%) Invasive Ductal Carcinoma (IDC); 14 pasien (66,67%) pada grade III; 8 pasien (38,10%) memiliki angioinvasion; 11 pasien (52,38%) memiliki ER/PR positif; dan 10 pasien (47,62%) memiliki Her-2 positif. Pada follow up didapatkan 8 pasien (38,10%) berada dalam kondisi baik, 5 pasien mengalami metastasis jauh (23,81%), dan 4 pasien meninggal (19,05%). Dua puluh satu bayi terlahir sehat (100%). Kesimpulannya, agresivitas PABC dapat dilihat dari besarnya persentase pasien yang datang pada stadium lanjut dan prognosis yang buruk.Kata Kunci: kanker payudara, kehamilan
Penanganan nipple discharge di RS Onkologi Surabaya ARIO DJATMIKO; WIWIEN RISTANTO; ISKANDAR ALI
Indonesian Journal of Cancer Vol 4, No 4 (2010): Oct - Dec 2010
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v4i4.115

Abstract

Nipple secretion in nonlactating period often creates anxiety. Frequently this was the reason women came to hospital to be examined. Not all nipple secretion can be defined as nipple discharge. The terminology of nipple discharge is spontaneous fluid secretion from single duct in the nipple in nonlactating women. Generally, nipple discharge is related to non cancerous cause. Yet, many researchers stated that nipple discharge is a sign of breast malignancy. Therefore, accurate diagnostic is vital to differentiate the normal and abnormal nipple discharge. In final analysis, there must be a correct procedure to decide whether nipple discharge is to be operated or not. From January 2007 to December 2009, 10,033 new patients came to Surabaya Oncology Hospital with breast complaints. It turned out 950 cases (9,47%) were malignant. Out of 10,033 patients, 510 (5.08%) complained of nipple secretion. From 510 nipple secretions, 62 were nipple discharge (0.62%). Following the indication, 15 out of 62 cases were operated duct exploration with result 10 were malignant and 5 were benign. From the 15 cases which were operated and preceded by ultrasonography (USG), duct dilatation can be seen. From 10 nipple discharge with malignancy, 7 cases (70%) did not display any Ca suspicion in their mammography examination. Malignancy cases were found more in older age: 7 cases (70%) were above 50 years old. From these 10 cases with malignancy, only 1 case clinically had palpable mass. Pathology anatomy report revealed 10 cancer cases, 1,1% from 950 all cases who came to RSOS from Januari 2007 until December 2010. 4 cases are insitu carcinoma, 1 nipple discharge with palpable mass, tumor was found 6x6x4 cm. There were 5 cases non cancer, 4 cases intraductal papilloma and 1 periductitis.