Oketani massage can stimulate the strength of the pectoralis muscle to increase milk production. Acupressure can increase endorphins, reduce pain, and make the body more relaxed. This study was to determine the effect of the combination of Oketani massage and acupressure on prolactin levels in post Sectio Caesarea (SC) mothers. This research was quasi-experimental with a pretest and posttest control group design. The study's results using the independent sample T-test analysis showed no difference in prolactin levels before breast treatment and a combination of Oketani and acupressure massage. There was a significant difference (p=0.002) in the treatment group after combining Oketani massage and acupressure for post SC mothers and prolactin levels after receiving breast care. This study showed a significant difference (p=0.002) in the treatment group after a combination of Oketani massage and acupressure for post SC was performed. In addition, there was a difference in prolactin levels in the treatment group before and after a combination of Oketani massage and acupressure with an average increase in prolactin levels, which was 151 g/ml (SDĀ±101) (p=0.001). However, there was no difference in the control group. Oketani massage combined with acupressure can be given to post SC mothers.