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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences The Journal of Experimental Life Sciences (JELS)
Muhaimin Rifa'i
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya. Jl. Veteran, Malang 65145, East Java, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology Medicine & Pharmacology Neuroscience

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Journal : The Journal of Experimental Life Sciences (JELS)

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Expression of IL-17 on Breast Cancer Mice Treated by Combination of Phyllanthus Urinaria and Catharanthus roseus Extract Aya Shofiyah; M. Sasmito Djati; Muhaimin Rifa'i
The Journal of Experimental Life Science Vol. 12 No. 2 (2022)
Publisher : Postgraduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2022.012.02.05

Abstract

This study aimed to evaluate the effect of combination Phyllanthus urinaria and Catharanthus roseus in breast cancer mice based on the expression of IL-17. 7,12-Dimethylbenz(α)anthracene (DMBA) was injected intraperitoneally into normal mice at dose 1.5 mg.kg-1 weight to obtain breast cancer mice. Total of 24 experimental mice divided into normal mice (N), breast cancer mice (K), breast cancer mice with cisplatin (C) treatment (5 mg.kg-1 weight), breast cancer mice with combination extract Dose 1 (P. urinaria 500 mg.kg-1 weigt + C. roseus 15mg.kg-1 weight), breast cancer mice with combination extract Dose 2 (P. urinaria 1000 mg.kg-1 weight + C. roseus 75mg.kg-1 weight), and breast cancer with combination extract Dose 3 (P. urinaria 2000 mg.kg-1 weight + C. roseus 375 mg.kg-1 weight). Cheral was given orally for 14 days. The level of IL-17 was evaluated by flow cytometry analysis. The combination can suppress the expression of IL-17 which down regulation of IL-17 indicate a good prognosis for the breast cancer mice, for 6.17% in breast cancer condition to 0.93% with Dose 3 treatment. The combination can be used as immunomodulatory agent in humoral immunity through the regulation of IL-17. Keywords: Breast cancer, Catharanthus roseus, IL-17, Phyllanthus urinaria
Co-Authors Aya shofiyah Moch Sasmito Djati