Cases of skin cancer caused by exposure to ultraviolet rays continue to increase from year to year. So far, the prevention of skin cancer uses inorganic sunscreen lotion, only a few use ingredients from plants. In this research, a sunscreen lotion formula was made using the basic ingredients of the balakacida plant extract (Chromolaena odorata). The research was carried out in 4 stages namely; (1) preparation of balakacida leaf samples, (2) preparation of extracts, (3) preparation of lotion, (4) testing of the quality of sunscreen lotion including; sun protection factor (SPF), homogeneity, spreadability and pH values. Testing the SPF value using the ultra violet spectroscopy method and testing the pH using a pH meter. The results showed that the ethanol extract of balakacida leaves was 21.5% and the sunscreen lotion was a light green semi-solid substance. The results of the lotion quality test showed that the value of SPF, homogeneity, spreadability and pH values were respectively 26.95 at a concentration of 10%, homogen, 5.6 cm and 6.7. Based on the results obtained, it can be concluded that a sunscreen lotion made from balakacida leaves is very good to be developed as a sunscreen lotion to prevent skin cancer.