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Journal : JURNAL KIMIA SAINTEK DAN PENDIDIKAN

PENENTUAN DISOLUSI PADA OBAT SENYAWA KETOPROFEN SECARA SPEKTROFOTOMETRI Renny Futeri; Pevi Riani
JURNAL KIMIA SAINTEK DAN PENDIDIKAN Vol. 7 No. 1 (2023): JURNAL KIMIA SAINTEK DAN PENDIDIKAN
Publisher : Program Studi Kimia - Universitas Sari Mutiara Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/kimia.v7i1.3868

Abstract

Research on dissolution determination of Ketoprofen compounds by Spectrophotometry. Ketoprofen is a non-steroidal anti-inflammatory drug compound (NSAID) that works as an anti-inflammatory. Anti-inflammatory here is a group of drugs used to reduce inflammation and relieve pain. The dissolution test is a method used to determine the content of active compounds that dissolve in drugs, where the time, temperature and media are set according to the human stomach and intestines, and can find out how much the content of active compounds dissolves in the human intestines and stomach. This dissolution test, then the ketoprofen drug is read by spectrophotometry. Test the dissolution by spectrophotometer at a wavelength of 260 nm using HCl 0.1 N and buffer pH 7.4. The results of the determination of the dissolution test of the active substance on ketoprofen at the acid stage obtained an average of 0.009% and at the pH 7.4 buffer stage obtained an average content of 86.4155%. It can be concluded that the determination of the ketoprofen dissolution test in the sample meets the requirements (MS), in accordance with the specifications of the Internal Standard of PT Novell Pharmaceutical Laboratories, namely at the acid stage not more than 10% of ketoprofen dissolved in 2 hours, and at the pH 7.4 buffer stage it has a requirement of 75%. ketoprofen dissolved in 45 minutes. In the dissolution of acidic media, 0.1 N HCl is used because its condition resembles that of the stomach.
PENENTUAN KADAR RESIDU PESTISIDA PROFENOFOS PADA TANAMAN TOMAT GAFHA DENGAN METODE GAS CHROMATOGRAPHY Renny Futeri
JURNAL KIMIA SAINTEK DAN PENDIDIKAN Vol. 7 No. 1 (2023): JURNAL KIMIA SAINTEK DAN PENDIDIKAN
Publisher : Program Studi Kimia - Universitas Sari Mutiara Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/kimia.v7i1.3869

Abstract

Research on determination of Profenofos Pesticide Residue Levels on Agafha Tomatoes Using Gas Chromatography Method has been carried out. The purpose of conducting research on samples of tomatoes that are often consumed by the community is to find out whether the tomato plants are suitable for consumption by the community or whether they have a negative impact if consumed frequently and to find out whether the tomato samples reach the maximum residue limit that has been set. After analyzing the Agaftha tomato samples in the pesticide laboratory, data was obtained that the Agaftha tomatoes contained prefenofos pesticide residues with a concentration of 0.0805 mg/kg, and the results of this test stated that the Agaftha tomato samples could be consumed properly because the concentration did not exceed the maximum residue limit. Prefenofos residue is regulated in the Regulation of the Minister of Agriculture of the Republic of Indonesia Number 55/PERMENTAN/KR.040/11/2015. The maximum residue limit (BMR) for the active ingredient profenofos is 10 mg/Kg. Hence, it can be concluded that the Agaftha tomato sample is suitable for consumption because the concentration of residue levels in the Agaftha tomato sample is lower than the BMR which has been regulated in the Regulation of the Minister of Agriculture of the Republic of Indonesia.
PENENTUAN JENIS MEDIA TERHADAP EFEKTIVITAS PERTUMBUHAN JAMUR TRICHODERMA HARZIANUM Pevi Riani; Renny Futeri
JURNAL KIMIA SAINTEK DAN PENDIDIKAN Vol. 7 No. 1 (2023): JURNAL KIMIA SAINTEK DAN PENDIDIKAN
Publisher : Program Studi Kimia - Universitas Sari Mutiara Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/kimia.v7i1.3909

Abstract

This study aims to determine a suitable medium for the growth Trichoderma harzianum. The treatments tested were rice media (M1), bran media (M2), corn media (M3), potato media (M4), and rice husk mixed media (M5). The parameters observed in this study were the quality test of conidia density using a microscope and haemacytometer, macroscopic observation of the media for 7 days and microscopic observation of the media to evaluate the media that had the best effectiveness as a medium for propagation of Trichoderma harzianum. The initial isolate of Trichoderma harzianum used had a conidia density of 2,9x109conidia/ml. The results showed that the propagation of Trichoderma harzianum in various media affected the macroscopic, microscopic and conidia density changes of Trichoderma harzianum. Trichoderma harzianum can grow on all treatment media. The bran media is the medium with the highest conidia density compared to other media.