This study aims to examine the effect of population growth rate and inflation on poverty in Indonesia. The data used in this study is time series data starting from 2001-2021. This study used secondary data obtained from publication documentation from the Indonesian Central Bureau of Statistics (BPS). The data analysis method used is multiple linear regression with the E-Views 9 program. The results showed that the partial rate of population growth had a negative and insignificant effect on poverty. The variable inflation partially has a positive and significant effect on poverty. Simultaneously, the rate of population growth and inflation have a significant effect on poverty in Indonesia. The value of the coefficient of determination shows that the rate of population growth and inflation is able to explain poverty by 33.77%.