Background:Inappropriate use of drugs is a big problem all over the world. The COVID-19 pandemic causes people to be easily influenced by information circulating about drugs that are efficacious to ward off COVID-19 so that many people consume excess drugs to protect themselves from COVID-19. The COVID-19 pandemic has also caused people to take health supplements to protect themselves from COVID-19.Objective:The purpose of this study was to determine the factors that influence drug use during the COVID pandemic.Methods:This research was an observational study with a cross sectional design. Sample was 115 respondents chosen by purposive sampling. Bivariate statistical test used was chi-square and multivariate test used was binary logistic regression. Results:Bivariate analysis result showed that age and distance from health care service did not significantly affect the drug use (p value > 0,05). Education, occupation, income, knowledge were significantly influence the drug use (p value < 0,05). In the multivariate analysis, the OR for education was 4,807, OR for occupation was 4,612, OR for income was 0.146. OR for knowledge 3,400.Conclusion:It can be concluded that the factors that significantly affect the use of drugs in the household environment of the Kota Sub-District Kudus Regency during the COVID-19 pandemic are occupation, education, income and knowledge