Curriculum changes occur because the curriculum needs to keep up with the demands and needs of the times to produce good products. Differentiated learning is one solution that can be used to overcome differences in student readiness, interests, and learning profiles. The purpose of this article is to further analyze the Application of Differentiated Learning in the Implementation of the Independent Curriculum in Grade 6 of Pleret Lor State Elementary School. The research design used is qualitative descriptive to analyze the application of the Differentiated learning model. The result of this study is that the application of Differentiated Learning in the Implementation of the Independent Curriculum in Grade 6 of Pleret Lor State Elementary School can be carried out actively and effectively. This is aimed at increasing the enthusiasm for learning and also the concentration of student learning in every differentiated learning. Differentiated Learning in the Implementation of the Independent Curriculum can make learning student-centered. The learning process carried out is also in accordance with the interests, potentials and talents of diverse students.