The skin is the outermost vital organ and is susceptible to various diseases, including skin cancer. The number of cases of skin cancer around the world continues to increase every year, including in Indonesia. Proper handling is very important to cure skin cancer, and one of the solutions that can be used is the Deep Learning method. This study aims to apply the Deep Learning method, specifically an object detection algorithm called You Only Look Once (YOLO), for early skin cancer detection. The YOLOv5s algorithm was chosen as the model for this study because it has good accuracy and can detect objects in real-time. The research method involved collecting data on skin cancer cases and training the YOLOv5s model. After training, model testing was carried out to evaluate the ability to detect skin cancer. The test results show that the YOLOv5s model has an accuracy of 89.1% in detecting skin cancer types. This research has important implications in the health sector, especially in early skin cancer detection.