Article Per Year (5 Year)
p-Index From 2019 - 2024
0.23
P-Index
This Author published in this journals
All Journal Indonesian Journal of Biomedicine and Clinical Sciences
Sumadi Lukman Anwar
Department of Surgery, Oncology Division, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/ Sardjito General Hospital, Yogyakarta, Indonesia.
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Indonesian Journal of Biomedicine and Clinical Sciences

 1 
Association between CDK4 expression and overall survival of osteosarcoma patients Faizah Dwi Tirtasari; Fikar Arsyad Hakim; Yudha Mathan Sakti; Sumadi Lukman Anwar; Rheza Gandi Bawono; Ery Kus Dwianingsih
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 01 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i01.11896

Abstract

Osteosarcoma is the most common primary bone tumor malignancy, accounting for 30 - 80% of all primary bone tumors. It is presented in a bimodal distribution manner with the age of onset divided into two groups, 10-20 and >60 y.o. Various factors have significance in the patient's prognosis, including the expression of cyclin-dependent kinase 4 (CDK4). This CDK4 has an essential role in the pathogenesis of osteosarcoma through inactivation of the Rb gene, which is associated with the patient's survival. This study was conducted to evaluate the correlation between CDK4 expression and the survival of osteosarcoma patients. It was a cross-sectional study involving 50 patients diagnosed with osteosarcoma based on clinical, radiological, and histopathological examination. Available formalin-fixed paraffin-embedded (FFPE) samples were retrieved for immunohistochemical (IHC) staining of CDK4. The survival data was collected from medical records. CDK4 expression and survival data were analyzed statistically using the Kaplan-Meier curve. Out of 50 subjects, CDK4 was found to be expressed in 38 samples (76%). The group with negative CDK4 showed a slightly longer overall survival (by 0.2 mo) than the positive CDK4 group. However, these results were not statistically significant (p = 0.821). In conclusion, the overexpression of CDK4 may not directly affect the survival rate in osteosarcoma. Other factors need to be considered to understand the complexity of the disease.
Co-Authors Ery Kus Dwianingsih Faizah Dwi Tirtasari Fikar Arsyad Hakim Rheza Gandi Bawono Yudha Mathan Sakti