The purpose of this study is to determine the impact of Micro, Small and Medium Enterprises (MSMEs) on Indonesia's economic growth from 2015 to 2022. The type of research used is quantitative descriptive research using time series data which is secondary data obtained from the Ministry of Cooperatives and Small and Medium Enterprises and the Central Statistics Agency (BPS). Simple regression analysis, t-test, and coefficient of determination (R2) were used for hypothesis testing. Based on the results of the t-test, it was concluded that MSMEs had a significant influence on Indonesia's economic growth from 2015 to 2022. Statistical analysis confirms a substantial impact, with MSMEs contributing around 80.2% to the variation in economic growth, as indicated by the coefficient of determination (R²). This shows that MSMEs play a crucial role in driving economic development in Indonesia during the research period. This study concludes that Micro, Small, and Medium Enterprises (MSMEs) have a significant and positive impact on Indonesia's economic growth from 2015 to 2022. The contribution of MSMEs, which reaches around 80.2% of the variation in economic growth, emphasizes their crucial role in the country's economic development. This highlights the importance of supporting and increasing MSME activities to encourage sustainable economic progress.