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All Journal Jurnal Kedokteran Brawijaya Research Journal of Life Science Majalah Kesehatan FKUB Indonesian Journal of Rheumatology CRJIM (Clinical and Research Journal in Internal Medicine)
Suryana, Bagus Putu Putra
Rheumatology And Immunology Division, Department Of Internal Medicine, Brawijaya University School Of Medicine-Saiful Anwar General Hospital, Malang
Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : Research Journal of Life Science

 1 
Potential of Topical Curcumin in Reduction of TNF-α expression and Synovium Hyperplasia on Wistar Rats of Rheumatoid Arthritis Model Ferri Widodo; Diana Lyrawati; Bagus Putu Putra Suryana
Research Journal of Life Science Vol 3, No 1 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (777.494 KB) | DOI: 10.21776/ub.rjls.2016.003.01.6

Abstract

Rheumatoid arthritis is a chronic inflammatory autoimmune disease associated with articular and systemic effects. This disease affects synovial joints covered by a special tissue called synovium. Curcumin has a potent antioxidant, antiinflammatory agent, antiangiogenic and anticarcinogenic. Curcumin can downregulate the expression of various proinflammatory cytokines and is reported beneficial effects in arthritis, but has a poor solubility dan bioavailability as well. The purpose of this research was to study the potential of liposomes topikal curcumin in reducing athritis score, reducing the expression of TNF-α and histopathological synovium hyperplasia of hind paw on Wistar rats with CFA that had been treated with topical curcumin. In this study, rats were divided into 7 groups: positive control, negative control, rheumatoid arthritis with topical curcumin therapy of 90 mg/kg BW, rheumatoid arthritis with topical curcumin therapy of 110 mg/kg BW, rheumatoid arthritis with topical curcumin therapy of 200 mg/kg BW, rheumatoid arthritis with methotrexate therapy, rheumatoid arthritis with placebo therapy. Results from this experiment indicated that topical curcumin has no significant to the arthritis score, significantly effect to percentase expression of TNF-α (p<0.05) and could decrease synovium hyperplasia based on histophatology examination. It could be concluded that therapy of topical curcumin could decrease the expression of TNF- α and synovium hyperplasia in rheumatoid arthritis rat. 
Co-Authors A S Haribowo Anna Ariane Anna Ariane Dian Hasanah Dian Hasanah Diana Lyrawati Endy Adnan Faisal Parlindungan Gatoet Ismanoe Handono Halim Handono Kalim Haribowo, A S Harry Isbagio Kalim, H Kusworini Handono Kusworini Handono Kusworini Handono Laniyati Hamijoyo Linda Kurniaty Wijaya Lya Rosita Mat Suwito Megawanto, Nur Handy Nursamsu Djais Nurshanty, Ade Praja, Dewangga Wahyu Pratama, Mirza Zaka Puspitasari, L Radiyati Umi Partan Rakhma Yanti Hellmi RM Suryo Anggoro Rudy Hidayat Rulli Rosandi Sari, Retty Kharisma Sariningsih, Fajar Shinta Oktya Wardhani, Shinta Oktya Sri Andarini Sumariyono Sumariyono Surya Darma Suwito, Mat Wahono, Cesarius Singgih Wahyu Dewi Tamayanti, Wahyu Dewi Widodo, Ferri Yulyani Werdiningsih