<![CDATA[Sea cucumber (Holothuria scabra) and Kersen leaf (Muntingia calabura L.) are used as traditional medicines that have anti-inflammatory activity. This study aims to determine the anti-inflammatory activity of a combination of ethanol extract of sea cucumber sand and Kersen leaves on the decrease of edema in the feet of rats that have been induced with 1% carrageenan. The rats were then divided into 5 groups and each group consisted of 3 rats. Group 1 as positive control, group 2 as negative control, group 3 as extract combination 1: 1 (200 mg / kg body weight: 200 mg / kg body weight), group 4 as extract combination 1: 2 (200 mg / kg body weight: 400 mg / kg body weight) ), group 5 as extract combination 2: 1 (400 mg / kgBB: 200 mg / kgBB), and each group is given orally. At 2: 1 EK has the same anti-inflammatory effect as positive control with% DAI, which is 4.84%. Whereas at EK 1: 2 with% DAI 4.24% and EK 1: 1 with% DAI 1.81%.]]>
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