Jurnal Kesehatan Bakti Tunas Husada
Vol 18, No 1 (2018)

KINETIC SOLUBILITY OF MEBENDAZOLE NANOCRYSTAL

Dzakwan, Muhammad ( Faculty of Pharmacy, University Setia Budi, Surakarta, Central Java)



Article Info

Publish Date
28 Mar 2018

Abstract

MBZ nanosuspensions were produced by high pressure homogenization and transformed into dry powder by lyophilization. MBZ nanocrystals were intensively evaluated regarding their physicochemical properties with respect to particle size analyses, crystallinity and kinetic solubility. The particle size was determined by photon correlation spectroscopy (PCS. DSC and X-ray diffraction were used to study the crystalline state of MBZ nanocrystals. In a period of 1 week, the kinetic solubility was determined using a shaker water bath at 37O C. DSC and X-ray diffraction analyses showed that lyophilized MBZ nanocrystals prepared by high pressure homogenization remained in crystalline state. Lyophilized MBZ nanocrystals could be re-dispersed completely in water and the kinetic solubility in water increased 9 fold, from 60,57 ηg/ml to 598 ηg/ml

Copyrights © 2018






Journal Info

Abbrev

P3M_JKBTH

Publisher

Subject

Health Professions Public Health

Description

This is the an open access journal specialized in Nursing Sciences, Health Analyst, Pharmacy and other relevant fields JKBTH was registered e-ISSN: 2621-4660 with SK no. 0005.26214660/JI.3.1./SK.ISSN/2018 and p-ISSN : 1979-004X with SK no. 0005.07/Jl.3.02/SK.ISSN/2008. JKBTH which was established ...