Dentika Dental Journal
Vol. 22 No. 2 (2019): Dentika Dental Journal

Increasing of IFNγ Expression in Transformed Cells of Balb/c Mice Due to Ethanol Extract Cocoa Beans (Theobroma cacao): Peningkatan Jumlah Ekspresi IFNγ pada Mencit Balb/c yang Mengalami Transformasi Sel Akibat Pemberian Ekstrak Etanol Biji Kakao (Theobroma cacao)

Triwahyuni, Iin Eliana (Unknown)

Article Info

Publish Date
18 Oct 2019

Abstract

As current technology cannot cure cancer completely, prevention becomes the main choice. To prevent the development of cell transformation into cancer cells, polyphenols that are widely found in cocoa beans (Theobroma cacao) can be used. IFNγ plays an important role in immunity against cancer. This study aims to see the ability of cocoa beans ethanol extract to increase the number of IFNγ expression in Balb/c mice undergoing cell transformation. This study used three groups Balb/c (n=4), namely K1 (normal control), K2 (negative control: injected with benzopyrene without ethanol extract of cocoa beans), and K3 (treatment: injected with benzopyrene, given 4mg/30gBW/po/day ethanol extract of cocoa beans). The mice were biopsied, and IFNγ expression was examined by immune histochemical method. The results showed that IFNγ expression increased significantly in K3. It can be concluded that ethanol extract of cocoa beans could increase IFNγ expression in Balb/c mice undergoing cell transformation.

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Journal Info
Dentika Dental Journal
Website

Abbrev

dentika

Publisher

Universitas Sumatera Utara

Subject

Dentistry

Description

d e n t i k a DENTAL JOURNAL is one of the journals managed by TALENTA Universitas Sumatera Utara which first published in 2015. This is an online scientific journal that publishes articles and scientific work from Researches, Case Reports and Literature Reviews in Dentistry and Dental Science. The ...