The purpose of this research was to examine the effect of Information system quality; reliability, ease of use, flexibility, functionality, to user satisfaction. Responsees were collected from 392 user in three groups; lectures, operator system information and students of economics faculty universitas Syiah Kuala. The research hypotheeses were analyzed using multiple regresion.The result show reliability, flexibility, and functionality have strong influence on user satisfaction. While variable ease of use doesn’t influence on user satisfaction. Keywords: information system; quality, reliability, ease of use, flexibility, functionality, and user satisfaction.
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