PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia)
Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020

Cytotoxic Activity of Flavonols from Macaranga gigantea (Rchb.f. & Zoll.) Müll.Arg.

Rino Wanandri Salam Rewa (Universitas Airlangga)
Ratih Dewi Saputri (Universitas Airlangga)
Tjitjik Srie Tjahjandarie (Universitas Airlangga)
Mulyadi Tanjung (Universitas Airlangga)

Article Info

Publish Date
31 Dec 2020

Abstract

Two flavonols, glyasperin A (1), and meliternatin (2) has been isolated from the leaves of Macaranga gigantea (Rchb.f. & Zoll.) Müll.Arg. Extraction and isolation of flavonols were used methanol with the maceration method. The process of fractionation and purification used column chromatography and radial chromatography. The structure of both flavonols was determined by spectroscopic methods, including UV-Vis, IR, HRESIMS, 1D NMR (1H, and 13C-NMR) and 2D NMR (HMBC and HMQC). The cytotoxic activity of glyasperin A (1), and meliternatin (2) toward P-388 leukemia murine cells by MTT method, showing IC50 values 3.44 and 30.04 µg/mL, respectively.

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Journal Info
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia)
Website

Abbrev

PHARMACY

Publisher

Universitas Muhammadiyah Purwokerto

Subject

Materials Science & Nanotechnology

Description

PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) is a scientific journal publishing original articles research in pharmaceutical science such as Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical ...