Indonesian Journal of Health Science
Vol 1 No 2 (2021): Desember 2021

Peran Matriks Metalloproteinase 8 Pada Metastasis Sel Kanker Payudara

Mike Permata Sari (Politeknik Kesehatan Hermina)



Article Info

Publish Date
03 Dec 2021

Abstract

MMP-8 merupakan protease yang diproduksi oleh neutrofil dan berperan dalam degradasi kolagen yang terdapat pada jaringan ikat pada mamalia. Pada manusia, protein MMP-8 disandi oleh gen MMP-8. Pada umumnya, MMP disekresi dalam bentuk proprotein yang diaktifkan ketika dipecah oleh proteinase ekstraseluler. Peningkatan Ekspresi MMP-8 berlebih pada penderita kanker payudara di fase yang berbeda, peningkatan ekspresi MMP-8 tidak ditemukan pada sel payudara normal. MMP-8 memiliki substrat yang berbeda dengan MMP-2 dan MMP-9 yang berperan langsung dalam penyebab metastasis sel kanker payudara ke organ lain. Peran MMP-8 terhadap kanker payudara telah dilaporkan oleh penelitian sebelumnya bahwa MMP-8 mampu memicu metastasis kanker payudara melalui peningkatan sitokin proinflamasi yaitu IL-6 dan IL-8.  IL-6 dan IL-8 menginduksi metastasis melalui jalur persinyalan JAK/STAT3 yang akan mengaktifkan snail/slug/twist yang akan menekan ekspresi E-cadherin, selain itu IL-6 dan IL-8 memicu sintesis VEGF sehingga mengakibatkan pembentukan pembuluh darah baru. MMP-8 is a protease produced by neutrophils and plays a role in the degradation of collagen found in connective tissue in mammals. In humans, the MMP-8 protein is encoded by the MMP-8 gene. In general, MMPs are secreted in the form of proproteins that are activated when cleaved by extracellular proteinases. MMP-8 Ekspression increased in breast cancer patients at different stages, but it is not happenin normal breast cells. MMP-8 has a different substrate with MMP-2 and MMP-9 which play a direct role in causing breast cancer cell metastasis to other organs. The role of MMP-8 in breast cancer has been reported by previous studies that MMP-8 is able to trigger breast cancer metastasis through an increase in proinflammatory cytokines,such as IL-6 and IL-8. IL-6 and IL-8 induce metastasis through the JAK/STAT3 signaling pathway which will activate snail/slug/twist which will suppress E-cadherin expression, in addition IL-6 and IL-8 trigger VEGF synthesis, resulting in the formation of new blood vessels.

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Journal Info

Abbrev

ijhs

Publisher

Subject

Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

Description

Indonesian Journal of Health Science is a place for disseminating research results in the field of health, including, but not limited to topics of public health, environmental health, occupational health, pharmacy, nutrition, epidemiology, medical laboratories, physiotherapy, or other general ...