Walisongo Journal of Chemistry
Vol 3, No 1 (2020): Walisongo Journal of Chemistry

3D And 2D RNA Structure Prediction Of The BRCA2 Gene And Its Silencing RNA In The Breast Cancer

Ryan Wijaya (Department of Bioinformatics School of Life Sciences Indonesia International Institute for Life Sciences)
Arli Aditya Parikesit (Department of Bioinformatics School of Life Sciences Indonesia International Institute for Life Sciences)
Rizky Nurdiansyah (Department of Bioinformatics School of Life Sciences Indonesia International Institute for Life Sciences)



Article Info

Publish Date
14 Aug 2020

Abstract

Breast cancer is one of the most threatening diseases for women. It is found that BRCA2 gene plays a significant role in breast cancer, provided that mutations occurred. The objective of this study is to determine whether the bioinformatics approach could provide the gene networking, molecular simulation, and computational metabolomics information to shed the relation between BRCA2 gene mutation with breast cancer progression. The methods are utilizing molecular simulation tools to comprehend the biochemical interaction of BRCA2 gene with other oncogenic genes. Lastly, the molecular docking tool is devised to provide the molecular interactions information. It could be implied that the Computer-Aided Drug Design (CADD)-based in silico transcriptomics tools could provide the fine-grained information on the exact role of BRCA2 gene in the progression of breast cancer. The clinical impact of this study could only be measured after the wet laboratory experiment is conducted to validate the computational approach results

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Journal Info

Abbrev

wjc

Publisher

Subject

Chemistry

Description

Walisongo journal of chemistry is a peer reviewed and open access journal published by Chemistry Department, faculty of Science and Technology, UIN Walisongo Semarang. This journal covering all areas of chemistry including inorganic, organic, physic, analytic, biochemistry, and environmental ...