Jurnal Sains dan Kesehatan
Vol. 2 No. 1 (2019): Jurnal Sains dan Kesehatan

Alkaloid Furokuinolin dan Asam Sinamat Ter-O-Geranilasi dari Kulit Batang Melicope hookeri T.G. HARTLEY

Ratih Dewi Saputri (Lab. Kimia Organik Bahan Alam, Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Surabaya 60115, Indonesia)
Tjitjik Srie Tjahjandarie (Lab. Kimia Organik Bahan Alam, Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Surabaya 60115, Indonesia)
Mulyadi Tanjung (Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Surabaya 60115, Indonesia)

Article Info

Publish Date
30 Jun 2019

Abstract

One furokuinoline alkaloid, evolitrine (1), and one cinnamate acid, trans 3-methyl-4-geranil caffeic acid (2) were isolated from the stem bark of Melicope hookeri. The structures of both compounds were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their anticancer activity against murin leukemia P-388 cells, showing their IC50 were 4,06 ± 0,15 and 4,86 ± 0,30 µg/ml, and two compounds showed moderate activity.

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Journal Info
Jurnal Sains dan Kesehatan
Website

Abbrev

jsk

Publisher

Universitas Mulawarman

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

Description

Jurnal Sains dan Kesehatan (J. Sains. Kes) (e-ISSN 2407-6082, p-ISSN 2303-0267), is a national journal with ISSN and published four times a year in 2015. In 2016 the publishing frequency changed to twice a year. In 2021 the frequency increased to six times a year. Jurnal Sains dan Kesehatan is ...