Bioscientia Medicina : Journal of Biomedicine and Translational Research
Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research

Correlation Epidermal Growth Factor Receptor Mutation with Non-small Cell Lung Cancer in Passive Smokers: A Review

Yuda Nabella Prameswari (Master’s Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia / Faculty of Medicine, Universitas Sultan Ageng Tirtayasa, Cilegon, Indonesia)
Dwi Anita Suryandari (Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia)

Article Info

Publish Date
14 Feb 2022

Abstract

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with an extracellular epidermal growth factor binding domain and an intracellular tyrosine kinase domain through signaling pathways to regulate cellular proliferation. Epidermal growth factor receptor binding to its ligand will result in autophosphorylation by intrinsic tyrosine kinase activity, thereby triggering multiple signal transduction cascades. Constant or sustained activation of these downstream target sequences is thought to result in a more aggressive tumor phenotype. Mutations in EGFR are associated with non-small cell lung cancer in passive smokers.

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Journal Info
Bioscientia Medicina : Journal of Biomedicine and Translational Research
Website

Abbrev

bsm

Publisher

HM Publisher

Subject

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

Description

This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to : 1.Rhemumatology 2.Molecular aspect of Indonesia ...