<![CDATA[Doxorubicin as chemotherapeutic agent causes immunosuppresive. The aimàfor this study to determine the effect of ethanolic extract of Taraxacum oficinale (ETO) in immunity system of Sprague Dawleyàrat that inducedàby doxorubicin to observe the profile of immunity cells. Sprague Dawley rats were divided into five groups each groups contain five rats : control doxorubicin group, doxorubicin dose 4,67 mg/kgBW+ ETO dose 1000 mg/kgBW, doxorubicin dose 4,67 mg/kgBW+ ETO dose 500 mg/kgBW, control extract group, and without treatment. Then the number of leukocytes, lymphocytes and neutrophils were analyzedàby hematology analyzer, whereas CD8+ T lymphocytes by flowcytometry. Results showed groups ofàdoxorubicin combined with ETO dose 1000 mg/kgBW and 500 mg/kgBW increased the number of leukocytes, lymphocytes, neutrophils,àcytotoxic CD8 + T cellsàT cells comparedàto control doxorubicin group. These data presents that etanolic extract of Jombang leaves hasàimmunostimulatory activity and potential as co-chemotherapy agents. Molecullar mechanism underlaying itââ¬â¢s immune activity need to be explored in detail. ]]>
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