ALCHEMY Jurnal Penelitian Kimia
Vol 18, No 1 (2022): March

Sintesis, Karakterisasi, dan Uji Aktivitas Antibakteri Senyawa Organotimah(IV) 4-Nitrobenzoat

Sutopo Hadi (Jurusan Kimia, FMIPA, Universitas Lampung, Jl. S. Brojonegoro No. 1, Gedongmeneng, Bandar Lampung 35145)
Nova Tri Irianti (Jurusan Kimia, FMIPA, Universitas Lampung, Jl. S. Brojonegoro No. 1, Gedongmeneng, Bandar Lampung 35145)
Noviany Noviany (Jurusan Kimia, FMIPA, Universitas Lampung, Jl. S. Brojonegoro No. 1, Gedongmeneng, Bandar Lampung 35145)



Article Info

Publish Date
02 Feb 2022

Abstract

Dua buah senyawa organotimah(IV) yaitu berupa senyawa trifeniltimah(IV) 4-nitrobenzoat (2) dan difeniltimah(IV) di-4-nitrobenzoat (4) telah berhasil disintesis melalui reaksi antara senyawa trifeniltimah(IV) hidroksida (1) dan difeniltimah(IV) oksida (3) dengan ligan asam 4-nitrobenzoat (HNBA). Senyawa hasil sintesis dikarakterisasi dengan menggunakan spektrofotomer IR, spektrofotomer UV, spektrometer NMR dan microelemental analyzer untuk melihat kemurnian senyawa. Aktivitas biologis senyawa turunan organtotimah(IV) 4-nitrobenzoat telah diuji terhadap bakteri Gram positif Staphylococcus aureus dan Gram negatif Escherichia coli. Hasil uji dengan metode difusi agar menunjukkan senyawa 2 pada konsentrasi 200 ppm (3,87 × 10-4 M) memberikan penghambatan yang lebih efektif dibandingkan senyawa 4, senyawa awal 1 dan 3 serta ligan HNBA.Synthesis, Characterization, and Antibacterial Activity Test of Organotin(IV) 4-nitrobenzoate. Two organotin(IV) compounds, namely triphenyltin(IV) 4-nitrobenzoate (2) and diphenyltin(IV) di-4-nitrobenzoate (4) compounds have been successfully synthesized through a reaction between triphenyltin(IV) hydroxide (1) and diphenyltin(IV) oxide (3) with 4-nitrobenzoic acid (HNBA) The synthesized compounds were characterized using IR, UV, NMR spectrometer, and a microelemental analyzer to check the compound purity. The biological activity of the organotin(IV) 4-nitrobenzoate derivative was tested against Gram-positive bacteria S. aureus and Gram-negative bacteria E. coli. The test results with the agar diffusion method showed that compound 2 at a concentration of 200 ppm (3.87 x 10-4 M) provide more effective inhibition than compound 4, the starting materials 1 and 3, and the ligand HNBA.

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Journal Info

Abbrev

alchemy

Publisher

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology

Description

ALCHEMY Jurnal Penelitian Kimia is a chemistry journal published by Sebelas Maret University, Surakarta. ALCHEMY Jurnal Penelitian Kimia publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and ...