ALCHEMY Jurnal Penelitian Kimia
Vol 18, No 1 (2022): March

Synthesis and Molecular Docking Study of 4-(3-(2-Chlorophenyl)-5-(2-Methoxyphenyl)-4,5-Dihydro-1H-Pyrazol-1-yl) Benzenesulfonamide as Antibreast Cancer Agent

Eka Marisa Putri (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Jalan H.R. Subrantas KM. 12.5, 28293, Pekanbaru, Indonesia)
Noval Herfindo (Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi Riau, Jalan Kamboja, Simpang Baru, Tampan, Pekanbaru, Riau 28289 Indonesia)
Guntur Guntur (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Jalan H.R. Subrantas KM. 12.5, 28293, Pekanbaru, Indonesia)
Neni Frimayanti (Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi Riau, Jalan Kamboja, Simpang Baru, Tampan, Pekanbaru, Riau 28289 Indonesia)
Adel Zamri (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Jalan H.R. Subrantas KM. 12.5, 28293, Pekanbaru, Indonesia)

Article Info

Publish Date
03 Dec 2021

Abstract

Breast cancer is a disease in which cells in the breast tissue change and divide in an uncontrolled way. Pyrazoline is a promising agent reported against cancer. In this work, we have synthesized pyrazoline 4-(3-(2-chlorophenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide (EMP-1). The reaction was successfully carried out in one-pot three components from 2-chloroacetophenone, 2-methoxybenzaldehyde, and 4-hydrazinylbenzenesulfonamide as starting materials. The reaction was conducted by assisting the irradiation of Monowave 50 (Anton-Paar) with a high yield of 91%. Its potential anti-breast cancer was investigated by molecular docking and dynamic studies. The molecular docking study showed that EMP-1 had binding energy of -7.17 kcal/mol. The spatial arrangement of EMP-1 was similar to the positive control of doxorubicin. These results indicate that EMP-1 compound potentially developed as anti-breast cancer.

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Journal Info
ALCHEMY Jurnal Penelitian Kimia
Website

Abbrev

alchemy

Publisher

Universitas Sebelas Maret

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology

Description

ALCHEMY Jurnal Penelitian Kimia is a chemistry journal published by Sebelas Maret University, Surakarta. ALCHEMY Jurnal Penelitian Kimia publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and ...