EKSAKTA: Journal of Sciences and Data Analysis
VOLUME 3, ISSUE 1, February 2022

Routine Blood Profiles of Global Ischemic Rats Based on Ischemia Durations

Rika Yulita Rahmawati (Faculty of Medicine, Universitas Islam Indonesia)
Utami Mulyaningrum (Department of Clinical Pathology, Faculty of Medicine, Universitas Islam Indonesia)
Ety Sari Handayani (Department of Anatomy, Faculty of Medicine, Universitas Islam Indonesia)



Article Info

Publish Date
30 May 2022

Abstract

Stroke is the third cause of death and the first cause of disability in the world. It is around 80% of stroke patients in the world are ischemic stroke. According to the development of stroke models in animals, BCCAO is one technique that can induce global cerebral ischemia. An ischemia is known to influence activities of inflammatory cells which can be measured through peripheral blood. This study aims to determine effects of ischemia duration on routine blood profiles of rats (Rattus norvegicus) after bilateral common carotid artery occlusion (BCCAO). This study was a quasi-experimental study. Its subjects were adult Wistar rats (Rattus norvegicus). The rats were grouped into four treatment groups, and each group consisted of 6 rats. Group A was a group of sham-operated rats, group B was a group of rats with ischemia duration for 5 minutes, group C was a group of rats with ischemia duration for 10 minutes, and group D was a group of rats with ischemia duration for 20 minutes. Its obtained data were analysed by one-way ANOVA test and Post Hoc Tamhane's test. The ischemia duration significantly influenced the neutrophil and lymphocyte count after ischemia, with p < 0.05. The ischemia duration could affect the routine blood profiles of the rats after BCCAO, especially the neutrophil and lymphocyte count.

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Journal Info

Abbrev

eksakta

Publisher

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Materials Science & Nanotechnology

Description

Ekstakta is an interdisciplinary journal with the scope of mathematics and natural sciences that is published by Fakultas MIPA Universitas Islam Indonesia. All submitted papers should describe original, innovatory research, and modelling research indicating their basic idea for potential ...