Jurnal Ilmu Komputer dan Agri-Informatika
Vol 9 No 1 (2022)

Pemodelan Berbasis Jaringan untuk Pengklasifikasian Kanker Payudara Berdasarkan Data Molekuler

Mushthofa (Institut Pertanian Bogor)
Chamdan L Abdulbaaqiy (Institut Pertanian Bogor)
Sony Hartono Wijaya (Institut Pertanian Bogor)
Muhammad Asyhar Agmalaro (Institut Pertanian Bogor)
Lailan Sahrina Hasibuan (Institut Pertanian Bogor)



Article Info

Publish Date
31 May 2022

Abstract

Cancer is a disease characterized by uncontrolled cell growth. One of the characteristics of uncontrolled growth is the presence of estrogen-receptor-positive (ER+). About 67% of breast cancer test results have ER+. Breast cancer profiles are divided into 4 subtypes, namely: Luminal A, Luminal B, basal-like, and HER-2 enriched. Each category has a different effect on adjuvant chemotherapy. In this study, a network-based approach was used to select features/molecular biomarkers that have the potential to assist modeling and classifying sub-types of breast cancer. The molecular features used are Copy Number Alteration (CNA) and gene expression. The feature selection results were compared with the PAM50 feature-based accuracy from the literature study. The results indicate that the features selected from this network-based approach can obtain a comparable performance w.r.t the original PAM50 features, and can be used as alternative to perform breast cancer subtyping.

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Journal Info

Abbrev

jika

Publisher

Subject

Agriculture, Biological Sciences & Forestry Computer Science & IT

Description

Jurnal Ilmu Komputer dan Agri-Informatika (JIKA) diterbitkan setiap bulan Mei dan November, memuat tulisan ilmiah yang berhubungan dengan bidang Ilmu Komputer serta aplikasi informatika untuk pengembangan pertanian. Berkala ilmiah ini menerima tulisan hasil penelitian dari luar ...