<![CDATA[The family Rutaceae has plants with worldwide aphrodisiac effects, but their activity as an antidiabetic has not been widely reported. This study aims to predict the -amylase activity of aphrodisiac plant compounds from the Rutaceae family based on virtual screening. The -amylase receptor (PDB ID: 1XD1) was prepared using Pymol while the ligand was prepared using Pyrx. Virtual screening using Autodoct vina in Pyrx with acarbose as a control drug. The results of virtual screening were analyzed using Discovery Studio software to get potential compounds. Prediction of a potential compound target protein using Swiss Prediction Target while pharmacokinetic analysis is based on The lipinski rule. The results showed that lunamarine had the highest inhibitory activity (-8.9 Kcal/mol) against -amylase receptors and was close to acarbose control (-9.7 Kcal/mol). Lunamarine complies with the Lipinski rule and has a high probability of target protein. The study concludes that compounds from aphrodisiac plants from the family Rutaceae have antidiabetic activity. Lunamarin has the highest activity as an -amylase inhibitor compared to other compounds.]]>
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