MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan
Vol 9, No 2 (2022): August

Effect of Ethanol Extract of Basil Leaves (Ocimum basilicum) on the number of M2 Macrophages in the Kidneys of Mice (Mus musculus) Using the Unilateral Ureteral Obstruction (UUO) Method

Muhammad Achya Farhany (FK UMPurwokerto, Purwokerto)
Dewi Karita ([Sinta ID: 6695494] FK UMPurwokerto, Purwokerto)
Andi Muh. Maulana (FK UMPurwokerto, Purwokerto)
Mustika Ratnaningsih (FK UMPurwokerto, Purwokerto)

Article Info

Publish Date
04 Aug 2022

Abstract

Background: Chronic Kidney Disease (CKD) is a problem in nephrology with a fairly high incidence rate, the final condition of CKD is the presence of kidney fibrosis in the tubulointerstitial region depending on the polarization of macrophages. Basil antioxidant efficacious leaves can prevent damage to tubular cells in animals.Objective: To determine the effect of giving basil leaf extract (Ocimum basilicum L.) on the amount of M2 macrophages in mice (Mus musculus) with the Unilateral Ureteral Obstruction method.Methods: This research use an experimental study using a posttest only with randomized controlled group design.Results: Data on administration of basil leaf extract (Ocimum basilicum L.) to mice can reduce damage to the kidneys analyzed using LSD test obtained p value (0.000 <0.005). The amount of M2 macrophages in mice given basil ethanol extract with the largest dose was 24 mg /20grBW compared to the administration of basil ethanol extract at a dose of 12 mg/20grBW and 48mg/20grBW.Conclusion: Administration of basil leaves extract (Ocimum basilicum L. ) in mice can reduce damage to the kidneys.

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Journal Info
MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan
Website

Abbrev

APKKM

Publisher

Universitas Muhammadiyah Semarang

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Magna Medica is a medical journal of APKKM contains papers and scientific articles created as a form of realization Tridharma college. The journal is published every six months, April and October of three articles in the form of: - Research article - Case report - Literature review The scope of this ...