Jurnal RSMH Palembang
Vol. 3 No. 1 (2022): Jurnal RSMH Palembang

The Roles of Extracellular Matrix in Breast Carcinoma: A Narrative Literature Review

Eka Putra Pratama (Department of Pathological Anatomy, Faculty of Medicine, Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia)
Citra Dewi (Department of Pathological Anatomy, Faculty of Medicine, Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia)

Article Info

Publish Date
17 Nov 2022

Abstract

The extracellular matrix is a complex and highly dynamic molecular network and serves to provide biochemical signals in the process of development, invasion, and metastasis of breast cancer. There are several proteins that contribute to the structure and function of the extracellular matrix, including collagen, laminin, glycosaminoglycans, and proteoglycans. Alterations of the extracellular matrix in breast cancer are not only limited to the composition of the extracellular matrix but also remodeling enzymes such as matrix metalloproteinase (MMP), cathepsin, urokinase plasminogen activator (uPA), lysyl oxidase (LOX) and heparanase. The extracellular matrix can increase breast cancer progressivity and resistance to treatment, so it is important to know its role because it can be a targeted therapy in the future.

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Journal Info
Jurnal RSMH Palembang
Website

Abbrev

JRP

Publisher

HM Publisher

Subject

Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

Description

JRP covers the major topics like Internal Medicine, Obstetric and Gynecology, Pediatric, Surgery, Ear Nose Throat, Neurology, Ophthalmology, Dermatovenerology, Anesthesia and Reanimation, Radiology, Pathology Anatomy, Clinical Pathology, Community Enpowerment, Manajemen of Hospital, Community ...