Malang Respiratory Journal
Vol. 4 No. 2 (2022): September 2022

A Rare Case: Adenocarcinoma Bronchogenic Dextra Std IVB on Gefitinib (15 months) accompanied by Decreased Visual Acuity, Bilateral Sensorineural Deafness and Psychiatric Disorders with No Radiological Evidence of Brain Metastasis

Caesar Ensang Timuda (Department of Pulmonology and Respiratory, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia)
Suryanti Dwi Pratiwi (Rumah Sakit Syaiful Anwar Malang)
Dessika Rahmawati (Department of Neurology, Saiful Anwar General Hospital, Brawijaya University)
Dearisa Yudhantara (Department of Psikiatri, Saiful Anwar General Hospital, Brawijaya University)
Dini Erawati (Department of Radiology, Faculty of Medicine, Universitas Brawijaya)
Dyah Indrasworo (Department of Otorhinolaringology, Saiful Anwar General Hospital, Brawijaya University)
Seskoati Prayitnaningsih (Department of Ophtalmology, Saiful Anwar General Hospital, Brawijaya University)

Article Info

Publish Date
30 Sep 2022

Abstract

Background: Leptomeningeal disease occurs in 3-5% of patients with lung cancer, mainly adenocarcinoma subtype. Adenocarcinoma is the most common histological finding in Asian women. Case: A 51-year-old woman with right-sided bronchogenic adenocarcinoma T4N3M1c Std IVB mutation(+) developed decreased vision, severe bilateral sensorineural deafness and psychiatric disorders after receiving Gefitinib 15 months. There was no evidence of brain metastasis from brain MRI. From evaluation of chest CT-scan, we found the disease was progressive and no Mutation Detected from ctDNA, so Gefitinib was discontinued. Conclusion: We found some difficulties in evaluating side effects of therapy and disease progression due to patient's condition in the form of decreased total vision, severe sensorineural deafness, and psychiatric disorders. However, because no radiological evidence of brain metastases was found, we suspect this patient suffered from leptomeningeal disease. Keywords: Lung Cancer, Adenocarcinoma, Gefitinib, Leptomeningeal Disease

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Journal Info
Malang Respiratory Journal
Website

Abbrev

mrj

Publisher

Universitas Brawijaya

Subject

Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

Description

Malang Respiratory Journal is the official open-access journal of Department of Pulmonology Respiratory Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. It publishes articles two times per year. It is a peer reviewed publication of Indonesian Pulmonology and Respiratory ...